HER3 expression is enhanced during progression of lung adenocarcinoma without EGFR mutation from stage 0 to IA1.
HER3 expression is enhanced during progression of lung adenocarcinoma without EGFR mutation from stage 0 to IA1.
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DOI：
10.1111/1759-7714.12609
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发表时间：
2018-04
期刊：
影响因子：
2.9
通讯作者：
Imamura F
中科院分区：
文献类型：
--
作者：
Kumagai T;Tomita Y;Nakatsuka SI;Kimura M;Kunimasa K;Inoue T;Tamiya M;Nishino K;Susaki Y;Kusu T;Tokunaga T;Okami J;Higashiyama M;Imamura F
激活EGFR突变、HER 2和HER 3与肺癌有关;然而，除了携带EGFR突变的肺腺癌中的EGFR基因扩增外，对它们在早期阶段参与疾病进展的情况了解甚少。在这篇文章中，我们重点研究了在EGFR从0期到IA 1期突变存在或不存在的情况下，哪种受体与肺腺癌进展相关。分别通过免疫组织化学和肽核酸锁核酸PCR钳方法检测了胸部计算机断层扫描显示毛玻璃结节并重新分类为0期和IA 1期的手术切除肺腺癌中HER 2和HER 3的表达和激活EGFR突变。分别在22.2%和86.1%的样本中检测到HER 2和HER 3表达。EGFR突变的频率为45.7%，0期和IA 1期之间无显著差异（分别为40.0%和48.0%），表明EGFR突变与癌症从0期进展至IA 1期无关。HER 2表达也与疾病进展无关。然而，在IA 1期肺腺癌中，尤其是在无EGFR突变的肺腺癌中，HER 3表达的频率和强度均增加。HER 3在无EGFR突变的肺腺癌从原位癌向浸润癌发展过程中有强烈表达的趋势。
Activating EGFR mutations, HER2, and HER3 are implicated in lung cancer; however, with the exception of EGFR gene amplification in lung adenocarcinoma harboring EGFR mutations, their involvement in disease progression during the early stages is poorly understood. In this paper, we focused on which receptor is correlated with lung adenocarcinoma progression in the presence or absence of EGFR mutation from stage 0 to IA1. HER2 and HER3 expression and activating EGFR mutations in surgically resected lung adenocarcinoma exhibiting ground glass nodules on chest computed tomography and re‐classified to stage 0 and IA1 were examined by immunohistochemistry and peptide nucleic acid‐locked nucleic acid PCR clamp method, respectively. HER2 and HER3 expression was detected in 22.2% and 86.1% of samples, respectively. The frequency of EGFR mutation was 45.7% and was not significantly different between stage 0 and IA1 (40.0% and 48.0%, respectively), suggesting that EGFR mutation does not correlate with cancer progression from stage 0 to IA1. HER2 expression also did not correlate to progression. However, not only the frequency, but also the intensity of HER3 expression was increased in stage IA1 lung adenocarcinoma, particularly in lung adenocarcinoma without EGFR mutation. HER3 tends to be intensively expressed during the progression of lung adenocarcinoma without EGFR mutation from carcinoma in situ to invasive carcinoma.
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影响因子：
158.5
作者：
Lynch, TJ;Bell, DW;Haber, DA
通讯作者：
Haber, DA
影响因子：
28.2
作者：
Takezawa K;Pirazzoli V;Arcila ME;Nebhan CA;Song X;de Stanchina E;Ohashi K;Janjigian YY;Spitzler PJ;Melnick MA;Riely GJ;Kris MG;Miller VA;Ladanyi M;Politi K;Pao W
通讯作者：
Pao W
影响因子：
--
作者：
Yonesaka K;Kudo K;Nishida S;Takahama T;Iwasa T;Yoshida T;Tanaka K;Takeda M;Kaneda H;Okamoto I;Nishio K;Nakagawa K
通讯作者：
Nakagawa K
对医疗统计信息的自由使用的易于使用的软件“ EZR”的调查。
影响因子：
4.8
作者：
Kanda Y
通讯作者：
Kanda Y
DOI：
10.1073/pnas.87.13.4905
发表时间：
1990-07-01
影响因子：
11.1
作者：
PLOWMAN, GD;WHITNEY, GS;SHOYAB, M
通讯作者：
SHOYAB, M