Human papillomavirus in the oral mucosa of women with genital human papillomavirus lesions
Human papillomavirus in the oral mucosa of women with genital human papillomavirus lesions
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DOI：
10.1016/j.ejogrb.2005.09.009
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发表时间：
2006-05-01
影响因子：
2.6
通讯作者：
Witkin, Steven S.
中科院分区：
文献类型：
--
作者：
Giraldo, Paulo;Goncalves, Ana K. S.;Witkin, Steven S.
目的：人乳头瘤病毒（HPV）感染是世界范围内最常见的性传播疾病之一。我们确定的频率，HPV在口腔中的妇女和没有生殖器HPV lesions.Material和方法：所有的患者都看到在妇科，妇女健康中心和州立大学的坎皮纳斯，圣保罗，巴西和提交一般的身体和妇科检查加上口腔的评价。详细的历史调查了他们的性行为。采用聚合酶链反应检测口腔内HPV感染情况，检测对象为70例经病理组织学证实的生殖器HPV临床病变和70例经妇科、阴道镜和细胞学检查阴性的临床或亚临床HPV病变。结果：29例（20.7%）患者检出口腔内HPV感染。在阳性妇女中，26例（89.7%）生殖器HPV阳性，而生殖器HPV阴性者仅3例（2.7%）（p < 0.0001）。在有和没有生殖器HPV的患者的口腔中HPV的总体患病率分别为37.1%和4.3%（p < 0.0001）。口腔HPV的存在与口交的实践无关（22%对19%）。结论：HPV生殖器感染患者口腔粘膜中HPV的频率较高。(C)2005爱思唯尔爱尔兰有限公司保留所有权利。
Objectives: Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases worldwide. We determined the frequency of HPV in the oral cavity of women with and without genital HPV lesions.Material and methods: All patients were seen at the Department of Gynecology, Women's Health Center and the State University of Campinas, Sao Paulo, Brazil and submitted to a general physical and gynecological examination plus an evaluation of the oral cavity. Detailed histories investigated their sexual practices. HPV in the oral cavity was determined by polymerase chain reaction using consensus primers in 70 women presenting with histopathology-confirmed clinical HPV lesions in the genital region and 70 women negative by gynecological, colposcopic and cytological examination for clinical or subclinical HPV lesions.Results: Oral HPV was detected in 29 (20.7%) of the subjects. Among the positive women, 26 (89.7%) were also positive for genital HPVas opposed to only 3 (2.7%) who were genital HPV-negative (p < 0.0001). The overall prevalence of HPV in the oral cavity of patients with and without genital HPV was 37.1 and 4.3%, respectively, (p < 0.0001). The presence of oral HPV was unrelated to the practice of fellatio (22% versus 19%).Conclusion: Patients with HPV genital infection have a greater frequency of HPV in their oral mucosa. (C) 2005 Elsevier Ireland Ltd. All rights reserved.