DEVELOPMENTAL IMMUNOHISTOCHEMISTRY OF CATALASE IN THE HUMAN BRAIN
DEVELOPMENTAL IMMUNOHISTOCHEMISTRY OF CATALASE IN THE HUMAN BRAIN
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DOI：
10.1016/0006-8993(91)90314-l
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发表时间：
1991-08-16
期刊：
影响因子：
2.9
通讯作者：
HASHIMOTO, T
中科院分区：
文献类型：
--
作者：
HOUDOU, S;KURUTA, H;HASHIMOTO, T
对过氧化物酶体过氧化氢酶的免疫组织化学研究是在人类胎儿到成人的大脑中进行的。 过氧化氢酶阳性神经元在妊娠 27-28 周时出现在基底神经节、丘脑和小脑中，在 35 周时出现在额叶皮质中。 然后，它们的数量随着胎龄而增加。 免疫阳性染色的程度随着核周尺寸的增大而增加。 但随着产后年龄的增长，其程度逐渐降低。 另一方面，过氧化氢酶阳性神经胶质细胞在妊娠31-32周时出现在深层白质中，随着年龄的增长，它们的外观从深层白质转移到浅层白质。 这些结果表明，过氧化物酶体与人脑发育过程中的神经元生长和髓磷脂生成密切相关。
The immunohistochemical studies on a peroxisomal enzyme, catalase, were done on brains from human fetuses to adults. The catalase-positive neurons appeared in the basal ganglia, thalamus and cerebellum at 27-28 weeks of gestation, and in the frontal cortex at 35 weeks. They then increased in number with gestational age. The extent of immunopositive staining increased with enlargement of perikaryonal size. However, the extent gradually decreased with postnatal age. On the other hand, catalase-positive glia appeared in the deep white matter at 31-32 weeks of gestation, their appearance shifting from the deep to the superficial white matter with increasing age. These results suggest that peroxisomes are closely related to neuronal growth and myelinogenesis in the human brain during development.