Population connectivity patterns of genetic diversity, immune responses and exposure to infectious pneumonia in a metapopulation of desert bighorn sheep
Population connectivity patterns of genetic diversity, immune responses and exposure to infectious pneumonia in a metapopulation of desert bighorn sheep
复制标题
沙漠大角羊集合种群遗传多样性、免疫反应和感染性肺炎暴露的种群连通性模式
DOI：
10.1111/1365-2656.13885
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发表时间：
2023
影响因子：
4.8
通讯作者：
Jolles, Anna E.
中科院分区：
文献类型：
--
作者：
Dugovich, Brian S.;Beechler, Brianna R.;Dolan, Brian P.;Crowhurst, Rachel S.;Gonzales, Ben J.;Powers, Jenny G.;Hughson, Debra L.;Vu, Regina K.;Epps, Clinton W.;Jolles, Anna E.
生境破碎化是生物多样性丧失的一个重要驱动因素，可以通过旨在维持集合种群自然连通性的管理行动加以补救。连通性可以通过保持免疫遗传多样性和抗病能力来保护人口免受传染病的侵害。然而，连通性可能会加剧传染病在脆弱人群中传播的风险。我们跟踪了莫哈韦沙漠中一种新的绵羊肺炎支原体菌株在沙漠大角羊Ovis canadensis nelsoni集合种群中的传播，以研究种群间连通性的变化如何影响疾病的结果。在整个集合种群中检测到了绵羊肺炎，这表明这些种群中的许多种群的相对隔离并没有保护它们免受病原体的入侵。然而，我们发现，大角羊种群之间的连接与较高的免疫遗传多样性，保护性免疫反应和较低的疾病患病率。保护性免疫力的变化预测了个体大角羊的感染风险，并与遗传基因座的杂合性相关，遗传基因座与适应性和先天免疫信号传导有关。这些发现可能表明，群体连接性维持了该系统中大角羊群体的免疫遗传多样性，并对个体大角羊的免疫反应及其对致命病原体感染的易感性产生直接影响。我们的研究表明种群连接的遗传益处可能超过传染病传播的风险，并支持保持集合种群自然连接的保护管理。
Habitat fragmentation is an important driver of biodiversity loss and can be remediated through management actions aimed at maintenance of natural connectivity in metapopulations. Connectivity may protect populations from infectious diseases by preserving immunogenetic diversity and disease resistance. However, connectivity could exacerbate the risk of infectious disease spread across vulnerable populations.We tracked the spread of a novel strain ofMycoplasma ovipneumoniaein a metapopulation of desert bighorn sheepOvis canadensis nelsoniin the Mojave Desert to investigate how variation in connectivity among populations influenced disease outcomes.M. ovipneumoniaewas detected throughout the metapopulation, indicating that the relative isolation of many of these populations did not protect them from pathogen invasion. However, we show that connectivity among bighorn sheep populations was correlated with higher immunogenetic diversity, a protective immune response and lower disease prevalence. Variation in protective immunity predicted infection risk in individual bighorn sheep and was associated with heterozygosity at genetic loci linked to adaptive and innate immune signalling.Together, these findings may indicate that population connectivity maintains immunogenetic diversity in bighorn sheep populations in this system and has direct effects on immune responses in individual bighorn sheep and their susceptibility to infection by a deadly pathogen.Our study suggests that the genetic benefits of population connectivity could outweigh the risk of infectious disease spread and supports conservation management that maintains natural connectivity in metapopulations.