CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer
CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer
复制标题
CEACAM6促进胃癌肿瘤迁移、侵袭和转移
DOI：
10.1093/abbs/gmu001
复制
发表时间：
2014-04-01
影响因子：
3.7
通讯作者：
Yan, Min
中科院分区：
文献类型：
--
作者：
Zhang, Yunqiang;Zang, Mingde;Yan, Min
癌胚抗原相关细胞粘附分子6 （CEACAM6）在多种人类癌症中表达增加，其过表达与迁移、侵袭和体内转移增强有关。本研究报告CEACAM6在胃癌细胞系和肿瘤组织中表达上调。CEACAM6在MKN-45和SGC-7901 GC细胞中的过表达促进了体外迁移和侵袭以及胸腺小鼠的转移，而CEACAM6的下调抑制了MKN-28和SNU-16 GC细胞的迁移和侵袭。我们还观察到，当CEACAM6在SGC-7901细胞中过表达时，类固醇受体共激活因子（C-SRC）磷酸化增加。综上所述，这些结果表明CEACAM6在胃癌中作为癌蛋白起作用，可能是一个重要的转移性生物标志物和治疗靶点。
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) shows increased expression in a wide variety of human cancers, and its over-expression is associated with enhanced migration, invasion, and in vivo metastasis. Here, we reported that CEACAM6 was up-regulated in gastric cancer (GC) cell lines and tumor tissues. Overexpression of CEACAM6 in MKN-45 and SGC-7901 GC cells promoted migration and invasion in vitro and metastasis in athymic mice, whereas migration and invasion of MKN-28 and SNU-16 GC cells were suppressed by knockdown of CEACAM6. We also observed that steroid receptor coactivator (C-SRC) phosphorylation was increased when CEACAM6 was over-expressed in SGC-7901 cells. Taken together, these results suggested that CEACAM6 functions as an oncoprotein in GC and may be an important metastatic biomarker and therapeutic target.