Genetic analysis of mammalian G-protein signalling
Genetic analysis of mammalian G-protein signalling
复制标题
哺乳动物 G 蛋白信号传导的遗传分析
作者：
S. Offermanns;M. Simon
异源三聚体G蛋白是重要的信号蛋白，在哺乳动物生物体的所有细胞中起作用。小鼠多种G蛋白α亚基基因的失活突变导致了大多数意想不到的表型，并为其生物学作用提供了有趣的新见解。尽管一些Gα基因的失活导致了温和的表型，表明存在冗余或补偿机制，但其他G蛋白似乎发挥着高度特异性的生物学或发育作用。本文综述了基于基因失活研究的G蛋白功能的最新进展。
Heterotrimeric G-proteins are important signalling proteins which function in all cells of the mammalian organism. Inactivating mutations in a variety of G-protein α-subunit genes in mice resulted in mostly unexpected phenotypes and have provided interesting new insight into their biological roles. Whereas the inactivation of some Gα genes led to mild phenotypes suggesting the presence of redundant or compensatory mechanisms, other G-proteins appear to play highly specific biological or developmental roles. The purpose of this review is to summarize the current knowledge about G-protein functions based on gene-inactivation studies.