XENOGRAFTS - FUTURE-PROSPECTS FOR CLINICAL TRANSPLANTATION
XENOGRAFTS - FUTURE-PROSPECTS FOR CLINICAL TRANSPLANTATION
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DOI：
10.1016/0165-2478(91)90221-u
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发表时间：
1991-07-01
影响因子：
4.4
通讯作者：
WELSH, KI
中科院分区：
文献类型：
--
作者：
CAIRNS, TDH;TAUBE, DH;WELSH, KI
本文概述了在异种移植成为现实之前仍然需要克服的基本问题。它提供的证据表明，如果这些问题中的第一个（预先形成的或天然的猪抗体）可以克服，那么猪肾脏将：(a)不会对人类产生超急性排斥；并且(b)在目前使用的免疫抑制下，不会诱导大量新的原发性或继发性反应。它还简要说明了选择猪作为供体的理由，并概述了在考虑真正的猪到人移植之前我们认为必要的动物工作。
This paper outlines the basic problems that still need to be overcome before xenografting becomes a reality. It presents evidence that if the first of these problems (preformed or natural antibody to pig) can be overcome then pig kidneys will: (a) not hyperacutely reject from a human; and (b) will not, under currently used immunosuppression, induce massive new primary or secondary responses. It also makes brief justification of the use of the pig as the donor of choice and outlines what essential animal work we feel necessary before an actual pig-to-human transplant is contemplated.