p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours
p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours
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DOI：
10.1038/sj.onc.1202106
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发表时间：
1998-10-01
期刊：
影响因子：
8
通讯作者：
Gusterson, BA
中科院分区：
文献类型：
--
作者：
Crook, T;Brooks, LA;Gusterson, BA
在BRCA 1和BRCA 2突变等位基因的生殖系携带者中产生的乳腺肿瘤中以及在散发性乳腺肿瘤的对照系列中研究了p53的状态，在20/26（77%）BRCA 1相关、10/22（45%）BRCA 2相关和25/72（35%）等级匹配的散发性肿瘤中检测到p53表达，p53序列分析显示，该基因在33/50（66%）的BRCA相关肿瘤中发生突变，而7/20（35%）的散发性等级匹配肿瘤含有p53突变（P
The status of p53 was investigated in breast tumours arising in germ-line carriers of mutant alleles of BRCA1 and BRCA2 and in a control series of sporadic breast tumours, p53 expression was detected in 20/26 (77%) BRCA1-, 10/22 (45%) BRCA2-associated and 25/72 (35%) grade-matched sporadic tumours, Analysis of p53 sequence revealed that the gene was mutant in 33/50 (66%) BRCA-associated tumours, whereas 7/20 (35%) sporadic grade-matched tumours contained p53 mutation (P