Risk factors for male breast cancer - A case-control study from Scandinavia
Risk factors for male breast cancer - A case-control study from Scandinavia
复制标题
DOI：
10.1080/028418601750288181
复制
发表时间：
2001-01-01
期刊：
影响因子：
3.1
通讯作者：
Kristensen, A
中科院分区：
文献类型：
--
作者：
Ewertz, M;Holmberg, L;Kristensen, A
我们报告了一项基于人群的男性乳腺癌危险因素的病例对照研究。在一系列斯堪的纳维亚乳腺癌病例和匹配的对照中收集了广泛的先前建议的风险因素的数据。在1987-1991年的4年间，从丹麦、挪威和瑞典癌症登记处的通知中确定了组织学证实的乳腺癌病例（n = 282），其中156名男性可以接触并作出反应。对照是通过国家中央人口登记册确定的，并根据国家、性别和出生年份进行单独匹配。排除诊断为乳腺癌的对照组；780名控制者中有468人做出了回应。风险因素的数据是通过自我管理的问卷收集的，这些问卷在确诊后1 - 2年内邮寄给病例，并在同一时期邮寄给对照组。研究结果与乳腺癌家族史(比值比（OR) = 3.3, 95%可信区间（CI） 2.0-5.6）、BMI指数为bbb30的诊断前10年肥胖（OR = 2.1, 95% CI 1.0-4.5）、糖尿病（OR = 2.6, 95% CI 1.3-5.3）以及地高辛和甲基多巴使用（OR分别= 2.0和2.1）相关的风险增加相一致。与乳腺癌家族史的关联已在几项研究中重复，而与人体测量的关系一直模棱两可。我们无法证实在其他研究中看到的一些关联；即具有高学历、生育能力、婚姻状况、睾丸损伤、肝病和宗教信仰的人群。关于女性乳房发育的详细问题表明，许多病例报告的乳腺癌症状为女性乳房发育，这种类型的误解可能解释了在其他研究中看到的与女性乳房发育的强烈联系。几名患者在接触前死亡。因此，与更具侵袭性的男性乳腺癌相关或与死亡高风险相关的风险因素（如肝硬化、重度吸烟）可能被忽略。
We report a population-based case-control study on risk factors for male breast cancer. Data on a broad range of previously suggested risk factors were collected in a set of Scandinavian breast cancer cases and matched controls. Incident cases (n = 282) with histologically verified carcinomas of the breast were identified from notification to the cancer registries of Denmark, Norway and Sweden over a 4-year period 1987-1991 and of these cases, 156 men could be approached and responded. Controls were identified through national central population registers and were matched individually for country, sex and year of birth. Controls with a diagnosis of breast cancer were excluded; 468 of 780 controls responded. Data on risk factors were collected by self-administered questionnaires mailed to the cases between land 2 years after diagnosis and to controls during the same period. The findings were compatible with an increased risk associated with family history of breast cancer (odds ratio (OR) = 3.3, 95% confidence interval (CI) 2.0-5.6), obesity 10 years before diagnosis (OR = 2.1, 95% CI 1.0-4.5) for BMI > 30, diabetes (OR = 2.6, 95% CI 1.3-5.3) and the use of digoxin and methyldopa (OR = 2.0 and 2.1, respectively). The association with family history of breast cancer has been repeated in several studies, while the relation to anthropometric measures has been equivocal. We could not substantiate some associations seen in other studies; namely those with high education, fertility, marital status, testicular injury, liver disease and religion. The detailed questions about gynaecomastia indicated that many cases reported signs of breast cancer as a gynaecomastia, This type of misunderstanding may explain the strong association with gynaecomastia seen in other studies. Several patients died before contact. Thus, risk factors related to a more aggressive male breast cancer or related to high risk of dying (e.g. liver cirrhosis, heavy smoking) may have been missed.