Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
复制标题
DOI：
10.1021/cm402592t
复制
发表时间：
2014-01-14
影响因子：
8.6
通讯作者：
Bein, Thomas
中科院分区：
文献类型：
--
作者：
Argyo, Christian;Weiss, Veronika;Bein, Thomas
具有高胶体稳定性的纳米介孔二氧化硅颗粒作为靶向治疗癌症的药物递送系统和生物成像装置越来越受到关注。这一观点描述了最近在介孔二氧化硅纳米粒子设计方面的突破，以证明其作为多功能药物递送纳米载体的高潜力。这些类型的纳米颗粒可以在纳米尺度上具有明确定义和可调的孔隙率，高负载能力以及用于靶向和进入不同类型细胞的多种功能。我们专注于一个有效的刺激响应，从而可控释放货物到癌细胞的要求，并讨论智能和自主纳米载体系统的设计原则。介孔二氧化硅纳米粒子被视为一个有前途的和灵活的平台，为许多生物医学应用。
Nanosized mesoporous silica particles with high colloidal stability attract growing attention as drug delivery systems for targeted cancer treatment and as bioimaging devices. This Perspective describes recent breakthroughs in mesoporous silica nanoparticle design to demonstrate their high potential as multifunctional drug delivery nanocarriers. These types of nanoparticles can feature a well-defined and tunable porosity at the nanometer scale, high loading capacity, and multiple functionality for targeting and entering different types of cells. We focus on the requirements for an efficient stimuli-responsive and thus controllable release of cargo into cancer cells and discuss design principles for smart and autonomous nanocarrier systems. Mesoporous silica nanoparticles are viewed as a promising and flexible platform for numerous biomedical applications.