CLINICAL AND ANTI-MICROBIAL EFFECT OF STANNOUS FLUORIDE ON PERIODONTITIS
CLINICAL AND ANTI-MICROBIAL EFFECT OF STANNOUS FLUORIDE ON PERIODONTITIS
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DOI：
10.1111/j.1600-051x.1981.tb02031.x
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发表时间：
1981-01-01
影响因子：
6.7
通讯作者：
SIMS, TN
中科院分区：
文献类型：
--
作者：
MAZZA, JE;NEWMAN, MG;SIMS, TN
本研究探讨氟化亚锡（SnF2）对慢性牙周病可疑致病菌斑的抗菌作用。采用暗视野显微镜观察了10例男性晚期牙周炎患者3个病变部位和1个牙周健康部位龈下和龈上菌斑细菌的形态学改变。此外，还测量了临床指标。3个病变部位分别用1.64%SnF2、0.4%SnF2或无菌生理盐水龈下冲洗。健康部位仅接受无菌生理盐水。在10周的时间内，每周观察患者，并在每次预约时测量细菌采样和临床指标。结果表明，1.64%SnF2引起龈下运动细菌和螺旋体的显着和持续的减少冲洗后。到第6周，这些细菌恢复到其原始浓度的50%。出血指数评分，这是显着减少，积极相关的减少运动细菌和螺旋体。用0.4%SnF2灌溉的站点也表现出类似的运动细菌和螺旋体减少模式，但没有完全消除它们，并且更快地恢复到原始水平。在接受无菌盐水的患病部位，运动细菌和螺旋体减少，与盐水冲洗相对应，迅速恢复到基线水平。健康对照部位无变化。龈上菌斑指数评分与出血指数、活动细菌和螺旋体或龈下冲洗无关。
The antimicrobial effect of stannous fluoride (SnF2) on suspected pathogenic morphotypes of bacterial plaque in chronic peridontal disease was assessed. Alterations in morphological groups of subgingival and supragingival plaque bacteria from 3 diseased sites and one periodontally healthy site were determined by darkfield microscopy in 10 male patients with advanced periodontitis. In addition, clinical indices were also measured. The 3 diseased sites received 1.64% SnF2, 0.4% SnF2 or sterile saline by subgingival irrigation. The healthy site received sterile saline only. The patients were seen weekly over a 10-wk period and at each appointment bacterial sampling and clinical indices were measured. Results indicated that 1.64% SnF2 caused a dramatic and sustained decrease of subgingival motile bacteria and spirochetes following irrigation. By the 6th wk these bacteria returned to 50% of their original concentration. Bleeding index scores, which were significantly reduced, correlated positively to the reduction in motile bacteria and spirochetes. Sites irrigated with 0.4% SnF2 also demonstrated a similar pattern of reduction of motile bacteria and spirochetes but without their total elimination and a more rapid return to original levels. In the diseased sites receiving sterile saline there was a decrease in motile bacteria and spirochetes, corresponding with saline irrigation, which rapidly returned to baseline levels. The healthy control sites were unchanged. Supragingival plaque index scores did not correlate with the bleeding index, motile bacteria and spirochetes, or with subgingival irrigation.