The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C
The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C
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DOI：
10.1111/j.1478-3231.2004.0927.x
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发表时间：
2004-08-01
影响因子：
6.7
通讯作者：
Maehara, Y
中科院分区：
文献类型：
--
作者：
Harimoto, N;Shimada, M;Maehara, Y
背景：最近的一份报告显示，热休克蛋白(HSP)-27的表达与肝细胞癌（HCC）患者的组织学分级和生存有关。目的：本研究的目的是研究HSP-27表达对日本HCC患者临床病理变量的影响。方法：应用单克隆抗HSP-27抗体对60例HCC患者进行HSP-27的免疫组化研究。我们将60例患者分为低表达HSP-27组（n=34）和高表达HSP-27组（n=26）。40名患者丙型肝炎病毒抗体检测呈阳性，20名患者乙型肝炎表面抗原检测呈阳性。结果：HSP表达与临床病理因素无相关性，高表达组与低表达组之间无差异。在乙型肝炎病毒（HBV）组（n=20）中，HSP-27的表达与预后、无病生存期（DFS）和总生存期显著相关。HBV组高表达与预后不良显著相关。相反，在HCV组（n=40）中，高表达的患者往往预后良好：DFS和总生存期。结论：本研究显示HSP-27可能在HBV和hcv相关的hcc中发挥不同的作用。
Background: A recent report showed that heat shock protein (HSP)-27 expression was related to histological grade and survival of patients with hepatocellular carcinoma (HCC). Aims: The aim of this study was to examine the effect of expression of HSP-27 on clinicopathological variables in Japanese patients with HCC. Methods: An immunohistochemical study for HSP-27 was performed on 60 HCC cases using a monoclonal anti-HSP-27 antibody. We divided 60 patients into two groups, patients with a low expression of HSP-27 (n=34) and those with a high expression of HSP-27 (n=26). Forty patients tested positive for the hepatitis C virus (HCV) antibody and 20 tested positive for the hepatitis B surface antigen. Results: There appeared to be no relationship between HSP expression and clinicopathologic factors and no differences were observed between the high expression group and the low expression group. In the hepatitis B virus (HBV) group (n=20), HSP-27 expression correlated significantly with prognosis, disease-free survival (DFS) and overall survival. High expression was significantly associated with poor prognosis in the HBV group. In contrast, patients with a high expression tended to have a good prognosis in the HCV group (n=40): DFS and overall survival. Conclusions: This study showed the possibility that HSP-27 plays different roles in HBV- and HCV-associated HCCs.