Associations between posttraumatic stress and stroke: A systematic review and meta-analysis.
Associations between posttraumatic stress and stroke: A systematic review and meta-analysis.
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创伤后应激与中风之间的关联：系统评价和荟萃分析。
DOI：
10.1002/jts.22925
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发表时间：
2023
影响因子：
3.3
通讯作者：
Lin,Chen
中科院分区：
文献类型：
--
作者：
Nanavati,HelyD;Arevalo,Andrea;Memon,AdeelA;Lin,Chen
本研究的目的是系统回顾现有文献，研究创伤后应激障碍（PTSD）和卒中风险之间的关联，并进行Meta分析，以获得描述该关联的汇总风险估计。在PubMed、Embase、PSYCInfo和CINAHL中进行文献检索，以识别相关研究。报告PTSD暴露的队列和横断面研究（即，分析中包括基线时PTSD诊断、可能的PTSD或存在PTSD症状）以及研究期间与PTSD暴露相关的卒中风险或几率。使用随机效应模型计算队列研究的合并风险比（HR），估计PTSD与卒中之间的关联。总体而言，11项研究符合纳入标准; 8项为队列研究，3项为横断面研究。两项队列研究和所有横断面研究使用PTSD症状的自我报告来衡量暴露。8项队列研究的合并风险比显示，患有PTSD与卒中事件风险增加59%相关，HR= 1.59，95%CI [1.36，1.86]，I2= 81%。在6项美国研究的亚组分析中，该相关性仍具有统计学显著性，HR= 1.38; 95% CI [1.29，1.49]，I2= 18%。研究结果表明，PTSD与中风风险增加有关。需要更多的研究来探索PTSD和中风之间的因果关系。
The objective of the present study was to systematically review the existing literature for studies examining the association between posttraumatic stress disorder (PTSD) and stroke risk and perform a meta‐analysis to obtain a pooled risk estimate describing the association. A literature search was conducted in PubMed, Embase, PSYCInfo, and CINAHL to identify relevant studies. Cohort and cross‐sectional studies that reported PTSD exposure (i.e., PTSD diagnosis, probable PTSD, or the presence of PTSD symptoms) at baseline and the risk or odds of stroke associated with PTSD exposure during the study period were included in the analysis. A random‐effects model was used to calculate the pooled hazard ratio (HR) for cohort studies estimating the association between PTSD and stroke. Overall, 11 studies met the inclusion criteria; eight were cohort studies, and three were cross‐sectional studies. Two cohort studies and all cross‐sectional studies used self‐report of PTSD symptoms to measure the exposure. The pooled hazard ratio for the eight cohort studies showed that having PTSD was associated with a 59% higher risk of incident stroke,HR= 1.59, 95% CI [1.36, 1.86],I2= 81%. The association remained statistically significant in a subgroup analysis of six United States–based studies,HR= 1.38; 95% CI [1.29, 1.49],I2= 18%. The findings suggest that PTSD is associated with an increased risk of stroke. More studies are required to explore a causal association between PTSD and stroke.