Survival of patients with esophageal atresia: Influence of birth weight, cardiac anomaly, and late respiratory complications
Survival of patients with esophageal atresia: Influence of birth weight, cardiac anomaly, and late respiratory complications
复制标题
DOI：
10.1016/s0022-3468(99)90231-2
复制
发表时间：
1999-01-01
影响因子：
2.4
通讯作者：
Sigalet, DL
中科院分区：
文献类型：
--
作者：
Choudhury, SR;Ashcraft, KW;Sigalet, DL
目的：本研究的目的是确定各种预后因素对食管闭锁patients.Methods的结果的影响：作者回顾了240个图表的患者承认食管闭锁或气管食管瘘（EA-TEF）在一个单一的机构。以生存率为因变量，以修复年龄、出生体重和心脏异常为自变量，采用Logistic回归模型。结果：年龄具有统计学意义（P = 0.011）; 87%（117/134）的患者在1980年至1997年期间存活，而1960年至1979年期间存活率为78%（83/106）。心脏异常（CHD）是一个重要的危险因素（P = 0.001）; 88%（176/199）无心脏异常存活，而只有59%（24/41）有心脏疾病存活。出生体重超过1,500克的婴儿中有84%（219人中的185人）存活，而出生体重低于1,500克的婴儿中有71%（21人中的15人）存活。这在统计学上不显著（P = 0.59）。早期医院死亡主要是心脏和染色体（61%）。晚期死亡主要是呼吸系统疾病（59%;双尾Fisher精确检验，P = 0.004）。结论：（1）近年来食管闭锁患者的生存率显著提高。(2)低出生体重（
Purpose: The aim of th is study was to determine the influence of various prognostic factors on the outcome of esophageal atresia patients.Methods: The authors reviewed 240 charts of patients admitted with esophageal atresia or tracheoesophageal fistula (EA-TEF) in a single institution. A logistic regression model was used with survival as the dependent variable and era of repair, birth weight, and cardiac anomaly as independent variables.Results: Era was statistically significant (P = .011); 87% (117 of 134) of patients survived in the era from 1980 through 1997 compared with 78% (83 of 106) from 1960 through 1979. Cardiac anomaly (CHD) was a significant risk factor (P = .001); 88% (176 of 199) survived without cardiac anomaly, whereas only 59% (24 of 41) survived with cardiac disease. Eighty-four percent (185 of 219) of infants with a birth weight (BW) of more than 1,500 g survived,compared with 71% (15 of 21) of infants with a birth weight of less than 1,500 g. This was not statistically significant (P = .59). Early hospital deaths were primarily cardiac and chromosomal (61%). Late deaths were primarily respiratory (59%; two-tailed Fisher's Exact test, P = .004).Conclusions: (1) Survival of patients with esophageal atresia has significantly improved in the recent years. (2) Low birth weight (