Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer
Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer
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DOI：
10.1016/j.biomaterials.2008.10.060
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发表时间：
2009-02-01
期刊：
影响因子：
14
通讯作者：
Strukelj, Borut
中科院分区：
文献类型：
--
作者：
Injac, Rade;Perse, Martina;Strukelj, Borut
研究了在阿霉素（Dox）诱导的结直肠癌大鼠心脏和肝脏组织中毒后，富勒烯醇C-60(OH)(24) （Frl）在25、50和100 mg/kg/周（持续3周）剂量下对心脏和肝脏组织的影响。在本研究中，我们使用Wistar雄性大鼠体内模型来探索Frl是否可以预防dox诱导的慢性心脏和肝脏毒性（1.5 mg/kg/周，持续3周），并将其与一种众所周知的抗氧化剂维生素C （100 mg/kg/周，持续3周）的效果进行比较。根据宏观、微观、血液学、生化、生理学、药理学和药代动力学结果，我们证实，在所有检测剂量下，Frl都对心脏和肝脏组织具有保护作用，防止Dox引起的慢性毒性。(C) 2008 Elsevier Ltd版权所有。
The effects of fullerenol C-60(OH)(24) (Frl) at closes of 25, 50, and 100 mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5 mg/kg/week for 3 weeks) chronic cardio- and hepato- toxicity and compared the effect with a well-known antioxidant, vitamin C (100 mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and phamacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox. (C) 2008 Elsevier Ltd. All rights reserved.