Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous system
Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous system
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DOI：
10.1002/dvdy.20577
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发表时间：
2005-11-01
影响因子：
2.5
通讯作者：
Schuurmans, C
中科院分区：
文献类型：
--
作者：
Alam, S;Zinyk, D;Schuurmans, C
在发育中的神经系统中，细胞命运规范和增殖是紧密耦合的事件，确保了适当数量和正确类型的神经元和胶质细胞的协调产生。虽然肿瘤抑制基因和癌基因是肿瘤细胞分裂的关键调控因子，但它们在正常细胞和发育过程中的作用尚不清楚。在这里，我们对多形性腺瘤基因（Plag）家族的三个成员的表达谱进行了比较分析，该家族编码锌指转录因子，以前被认为是肿瘤抑制因子（Zac1）或致癌基因（Plag1, Plag-l2）。我们将分析重点放在小鼠发育中的神经系统上，发现Plag基因在中枢和周围神经系统以及嗅觉和神经内分泌谱系中以独特和重叠的模式表达。基于它们的表达模式，我们认为Plag基因家族的成员可能控制着发育中的神经系统中的细胞命运和增殖决定，并提出解读这些功能将有助于解释为什么它们不适当的失活/激活导致肿瘤形成。
In the developing nervous system, cell fate specification and proliferation are tightly coupled events, ensuring the coordinated generation of the appropriate numbers and correct types of neuronal and glial cells. While it has become clear that tumor suppressor genes and oncogenes are key regulators of cell division in tumor cells, their role in normal cellular and developmental processes is less well understood. Here we present a comparative analysis of the expression profiles of the three members of the pleiomorphic adenoma gene (Plag) family, which encode zinc finger transcription factors previously characterized as tumor suppressors (Zac1) or oncogenes (Plag1, Plag-l2). We focused our analysis on the developing nervous system of mouse where we found that the Plag genes were expressed in both unique and overlapping patterns in the central and peripheral nervous systems, and in olfactory and neuroendocrine lineages. Based on their patterns of expression, we suggest that members of the Plag gene family might control cell fate and proliferation decisions in the developing nervous system and propose that deciphering these functions will help to explain why their inappropriate inactivation/activation leads to tumor formation.