In vivo efficacy of marimastat and chemoradiation in head and neck cancer xenografts.
In vivo efficacy of marimastat and chemoradiation in head and neck cancer xenografts.
复制标题
DOI：
10.1159/000163217
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Buchsbaum DJ
中科院分区：
文献类型：
--
作者：
Skipper JB;McNally LR;Rosenthal EL;Wang W;Buchsbaum DJ
目的：评价一种合成的基质金属蛋白酶抑制剂联合放化疗对小鼠头颈部鳞状细胞癌(SCC)模型肿瘤生长的影响。采用裸鼠SCC-1裸鼠移植瘤，分为4组：(1)对照组，(2)单用马利马特，(3)顺铂+放射联合治疗，(4)马利马特+顺铂+放射治疗。通过皮下渗透泵给药，每日8.7毫克/公斤，疗程14天。对照组只接受皮下渗透压泵给药。放疗分8、12、16、20天进行，共4次，每次照射前1h腹腔内注射顺铂3 mg/kg。与顺铂+放射联合治疗相比，接受三联治疗的动物生长延迟，测量为肿瘤倍增时间延长(p=0.03)。此外，与对照组相比，三联治疗组(p=0.005)在加倍时间方面延迟了生长。因子VIII免疫组织化学评估微血管密度没有显示三联治疗和顺铂+放射联合治疗组之间新生血管的减少。统计分析未能显示各组间有任何显著差异。与单纯放化疗相比，放化疗+马拉马特治疗延缓了肿瘤的生长。根据这些结果，马拉马特可能与化疗和放疗联合作用，以抑制肿瘤生长。
To assess the effect of combining a synthetic matrix metalloprotease inhibitor and chemoradiation therapy on tumor growth in a murine model of head and neck squamous-cell carcinoma (SCC). Athymic, nude mice bearing SCC-1 xenografts were used to comprise 4 treatment groups: (1) control receiving vehicle alone, (2) marimastat alone, (3) cisplatin + radiation in combination and (4) marimastat + cisplatin + radiation in combination. The marimastat was administered at a dose of 8.7 mg/kg/day over a 14-day period via a subcutaneous osmotic pump. The control group received vehicle only via a subcutaneous osmotic pump. Radiotherapy was given in 4 fractions of 8 Gy divided over days 8, 12, 16 and 20 with 4 intraperitoneal doses of cisplatin (3 mg/kg) 1 h before each fraction of radiation. Animals receiving triple treatment had delayed growth, measured as lengthened tumor doubling time, compared to the cisplatin + radiation combination (p = 0.03). Also, compared to control, the triple-treatment group (p = 0.005) had delayed growth in terms of doubling time. Factor VIII immunohistochemistry to assess microvessel density did not demonstrate a reduction in neovascularization between the triple-treatment and cisplatin + radiation combination groups. Statistical analysis failed to demonstrate any significant difference among groups. Chemoradiation + marimastat therapy had delayed tumor growth, compared to the chemoradiation alone. Based on these results, marimastat may work in combination with chemotherapy and radiation to inhibit tumor growth.
登录
查看更多内容
影响因子：
3.8
作者：
TEICHER, BA;HOLDEN, SA;GOFF, D
通讯作者：
GOFF, D
影响因子：
3.5
作者：
Lawrence, TS;Blackstock, AW;McGinn, C
通讯作者：
McGinn, C
影响因子：
15.9
作者：
Stetler-Stevenson, WG
通讯作者：
Stetler-Stevenson, WG
影响因子：
3.4
作者：
Heath, EI;Burtness, BA;Forastiere, AA
通讯作者：
Forastiere, AA
影响因子：
158.5
作者：
Bonner, JA;Harari, PM;Ang, KK
通讯作者：
Ang, KK