Non-Alcoholic Steatohepatitis Occurs in Celiac Disease and is Associated with Cellular Stress
Non-Alcoholic Steatohepatitis Occurs in Celiac Disease and is Associated with Cellular Stress
复制标题
DOI：
10.1055/s-0032-1330421
复制
发表时间：
2013-01-01
影响因子：
1.3
通讯作者：
Canbay, A.
中科院分区：
文献类型：
--
作者：
Kaesch, J. K.;Bechmann, L. P.;Canbay, A.
背景和目的：肝和肠不仅具有相同的消化功能，而且具有相同的免疫功能。主要组织相容性复合物I类相关链A和B（MIC A/B）用作细胞应激的指示物。这些所谓的应激诱导的配体被认为在非酒精性脂肪性肝病（NAFLD）的进展中起重要作用，并且是乳糜泻（CD）的突出特征。患者和方法：在本研究中，包括24例乳糜泻患者和20例非酒精性脂肪性肝炎（NASH）患者。结果：CD组患者平均年龄为42岁（18 - 69岁），NASH组患者平均年龄为49岁（33 - 68岁）。CD患者的ALT和AST值低于NASH患者。虽然NASH中的血清细胞死亡标志物较高，但CD中的主要细胞死亡类型是细胞凋亡。此外，与NASH患者相比，CD患者中MIC B的表达显著上调。NASH患者脂联素水平明显低于CD患者。结论：CD患者存在应激诱导配体和细胞凋亡。前瞻性研究需要确定细胞应激和细胞凋亡在肠-肝轴中的确切作用，以及CD患者筛查NAFLD的临床意义。
Background and Aims: Liver and gut not only share alimentary but also immunological features. Major histocompatibility complex class I-related chains A and B (MIC A/B) function as indicators for cellular stress. These so called stress-induced ligands are suggested to play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) and are a prominent feature of celiac disease (CD).Patients and Methods: In the present study, 24 patients with celiac disease and 20 patients with non-alcoholic steatohepatitis (NASH) were included. Liver enzymes, serum cell death markers (M30, M65), MIC B and expression of adiponectin were determined.Results: Mean patient age was 42 years (18 - 69) for CD and 49 years (33 - 68) for the NASH group. ALT and AST values were lower in CD compared to NASH patients. While serum cell death markers were higher in NASH, the predominant type of cell death in CD was apoptosis. Also, expression of MIC B was significantly up-regulated in CD patients as compared to NASH patients. Adiponectin values were significantly lower in NASH compared to CD patients.Conclusion: Stress-induced ligands and apoptosis are induced in CD. Prospective studies need to determine the exact role of cellular stress and apoptosis in the gut-liver axis and the clinical implications to screen for NAFLD in CD patients.