A retrospective study: form-deprivation myopia in unilateral congenital ptosis
A retrospective study: form-deprivation myopia in unilateral congenital ptosis
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DOI：
10.1111/j.1444-0938.2012.00716.x
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发表时间：
2012-07-01
影响因子：
1.9
通讯作者：
Zeng, Junwen
中科院分区：
文献类型：
--
作者：
Huo, Lijun;Cui, Dongmei;Zeng, Junwen
背景资料：这项回顾性研究的目的是探讨八岁以上患者单侧先天性上睑下垂与其屈光状态和等效球镜屈光度（SER）之间的关系。研究方法：该研究回顾了1998年至2010年期间中山大学附属第一医院收治的85例单侧先天性上睑下垂患者的临床记录。平均年龄为16.83岁（9至27岁）。根据眼睑下垂覆盖角膜的程度分为轻度（27例）、中度（37例）和重度（21例）。同侧眼作为对照。结果如下：在85只单侧上睑下垂的眼睛中，近视（SER为-0.50-D或更高近视）的频率显著高于对侧眼（47对32，p = 0.031）。重度单侧上睑下垂患者的近视发生率显著高于对侧眼（16对7，p = 0.012），而轻度（15/27对13/27，p = 0.79）或中度（16/37对12/37，p = 0.47）单侧上睑下垂患者的近视发生率无显著差异。同样，与对侧眼相比，重度上睑下垂眼的SER显著更近视（-1.37-D vs-0.85-D，p = 0.01），而轻度或中度单侧上睑下垂患者的SER无显著差异。结论：结果显示，与对侧眼相比，单侧重度上睑下垂眼的近视发生率更高，近视SER更多。单侧上睑下垂眼的近视可能是由类似于形觉剥夺动物近视的机制引起的。对于单侧上睑下垂患者，应注意可能存在的屈光不正。单侧上睑下垂应尽早手术矫正。
Background: The aim of this retrospective study was to investigate the relationship between unilateral congenital ptosis in patients older than eight years and their refractive state and spherical equivalent refraction (SER). Methods: The study involved a review of the clinical records of 85 patients admitted to the First Affiliated Hospital, Sun Yat-sen University between 1998 and 2010 with unilateral congenital ptosis. The average age was 16.83-years (nine to 27-years). The patients were classified into mild (27 cases), moderate (37 cases) or severe (21 cases) ptosis according to the degree of the droopy eyelid covering the cornea. The fellow eyes served as controls. Results: In 85 eyes with unilateral ptosis, the frequency of myopia (SER of -0.50-D or more myopia) was significantly higher than in the fellow eye (47 versus 32, p = 0.031). The frequency of myopia in eyes with severe unilateral ptosis was significantly higher than in the fellow eyes (16 versus 7, p = 0.012), whereas there were no significant differences in patients with mild (15/27 versus 13/27, p = 0.79) or moderate (16/37 versus 12/37, p = 0.47) unilateral ptosis. Similarly, the SER was significantly more myopic in eyes with severe ptosis compared with the fellow eye (-1.37-D versus -0.85-D, p = 0.01), whereas no significant differences were found in patients with mild or moderate unilateral ptosis. Conclusions: The results showed a higher frequency of myopia and more myopic SER in eyes with severe unilateral ptosis compared with the fellow eye. The myopia found in eyes with unilateral ptosis might be caused by a mechanism similar to that resulting in myopia among animals subjected to form deprivation. It is important to pay attention to possible refractive error in patients with unilateral ptosis. Surgical correction of unilateral ptosis at an early age is recommended.