Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
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DOI：
10.1016/s0896-6273(00)80755-2
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发表时间：
1999-05-01
期刊：
影响因子：
16.2
通讯作者：
Woolf, CJ
中科院分区：
文献类型：
--
作者：
Neumann, S;Woolf, CJ
成年哺乳动物CNS损伤后再生失败。我们研究了通过调节周围神经损伤来增加初级感觉神经元的内在生长状态是否会增加其中央轴突的再生长。在背柱损伤后，所有纤维都停止在损伤部位。外周轴突切断伴随中央病变的动物显示轴突生长到病变中，但不生长到病变上方的脊髓中。在背柱损伤前1或2周的预处理损伤导致生长进入损伤上方的脊髓。在体外，DRG神经突起的生长能力也增加后预处理损伤。因此，受损神经元的内在生长状态是中枢再生的关键决定因素。
Regeneration is abortive following adult mammalian CNS injury. We have investigated whether increasing the intrinsic growth state of primary sensory neurons by a conditioning peripheral nerve lesion increases regrowth of their central axons. After dorsal column lesions, ail fibers stop at the injury site. Animals with a peripheral axotomy concomitant with the central lesion show axonal growth into the lesion but not into the spinal cord above the lesion. A preconditioning lesion 1 or 2 weeks prior to the dorsal column injury results in growth into the spinal cord above the lesion. In vitro, the growth capacity of DRG neurite is also increased following preconditioning lesions. The intrinsic growth state of injured neurons is, therefore, a key determinant for central regeneration.