How Chimeric Antigen Receptor Design Affects Adoptive T Cell Therapy.
How Chimeric Antigen Receptor Design Affects Adoptive T Cell Therapy.
复制标题
DOI：
10.1002/jcp.25419
复制
发表时间：
2016-12
影响因子：
5.6
通讯作者：
Sentman CL
中科院分区：
文献类型：
--
作者：
Gacerez AT;Arellano B;Sentman CL
嵌合抗原受体（CAR） T细胞已被开发用于治疗肿瘤，并在治疗B细胞恶性肿瘤方面取得了巨大成功。利用模块化设计和可交换结构域，car可以靶向一系列细胞表面抗原，并在受体-配体相互作用时，直接信号级联，从而驱动T细胞效应功能。car被设计为使用受体、配体或scFv结合域。研究发现，CAR的不同区域在决定CAR - T细胞的整体功效方面都发挥着作用。因此，本文综述了CAR的结构和常见设计。每个CAR区域都在其对CAR功能的重要性的背景下进行讨论。此外，该综述还探讨了如何将各种工程策略应用于CAR - T细胞，以调节CAR - T细胞的功能和活性。
Chimeric antigen receptor (CAR) T cells have been developed to treat tumors and have shown great success against B cell malignancies. Exploiting modular designs and swappable domains, CARs can target an array of cell surface antigens and, upon receptor-ligand interactions, direct signaling cascades, thereby driving T cell effector functions. CARs have been designed using receptors, ligands, or scFv binding domains. Different regions of a CAR have each been found to play a role in determining the overall efficacy of CAR T cells. Therefore, this review provides an overview of CAR construction and common designs. Each CAR region is discussed in the context of its importance to a CAR’s function. Additionally, the review explores how various engineering strategies have been applied to CAR T cells in order to regulate CAR T cell function and activity.