Pd-Catalyzed Suzuki-Miyaura and Hiyama-Denmark Couplings of Aryl Sulfamates.
Pd-Catalyzed Suzuki-Miyaura and Hiyama-Denmark Couplings of Aryl Sulfamates.
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DOI：
10.1021/acs.orglett.6b02330
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发表时间：
2016-11-18
期刊：
影响因子：
5.2
通讯作者：
Williams MJ
中科院分区：
文献类型：
--
作者：
Melvin PR;Hazari N;Beromi MM;Shah HP;Williams MJ
使用最近发现的预催化剂，首次报道了在室温下发生的使用芳基氨基磺酸盐的钯催化铃木-宫浦反应。在补充工作中，证明相关的预催化剂可以促进芳基硅烷醇盐的偶联，芳基硅烷醇盐比硼酸与芳基氯的毒性和反应性亲核试剂更低。通过结合我们使用现代亲电子试剂和亲核试剂的结果，报道了第一个使用芳基氨基磺酸盐的桧山-丹麦反应。
Using a recently discovered precatalyst, the first Pd-catalyzed Suzuki–Miyaura reactions using aryl sulfamates that occur at room temperature are reported. In complementary work, it is demonstrated that a related precatalyst can facilitate the coupling of aryl silanolates, which are less toxic and reactive nucleophiles than boronic acids with aryl chlorides. By combining our results using modern electrophiles and nucleophiles, the first Hiyama–Denmark reactions using aryl sulfamates are reported.