Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.
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DOI：
10.1038/mp.2015.63
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发表时间：
2016-04
影响因子：
11
通讯作者：
Turner JA
中科院分区：
文献类型：
--
作者：
van Erp TG;Hibar DP;Rasmussen JM;Glahn DC;Pearlson GD;Andreassen OA;Agartz I;Westlye LT;Haukvik UK;Dale AM;Melle I;Hartberg CB;Gruber O;Kraemer B;Zilles D;Donohoe G;Kelly S;McDonald C;Morris DW;Cannon DM;Corvin A;Machielsen MW;Koenders L;de Haan L;Veltman DJ;Satterthwaite TD;Wolf DH;Gur RC;Gur RE;Potkin SG;Mathalon DH;Mueller BA;Preda A;Macciardi F;Ehrlich S;Walton E;Hass J;Calhoun VD;Bockholt HJ;Sponheim SR;Shoemaker JM;van Haren NE;Hulshoff Pol HE;Ophoff RA;Kahn RS;Roiz-Santiañez R;Crespo-Facorro B;Wang L;Alpert KI;Jönsson EG;Dimitrova R;Bois C;Whalley HC;McIntosh AM;Lawrie SM;Hashimoto R;Thompson PM;Turner JA
尽管几十年来使用脑扫描进行了研究，但精神分裂症患者大脑结构异常的概况仍未完全了解。为了验证分析多中心神经成像数据的前瞻性荟萃分析方法，我们分析了2028名精神分裂症患者和2540名健康对照的脑MRI扫描，并在全球15个中心使用标准化方法进行评估。我们确定了区分患者和对照组的皮质下脑体积，并根据他们的影响大小对他们进行了排名。与健康对照组比较，精神分裂症患者的海马体(−‘s d=0.46)、杏仁核(d=−0.31)、丘脑(d=−0.31)、伏隔核(d=−0.25)和脑体积(d=−0.12)较小，苍白球(d=0.21)和侧脑室(d=0.37)体积较大。壳核和苍白球体积增大与病程呈正相关，而海马区缺陷与未用药患者的比例成正比。全球对脑成像数据的合作分析支持精神分裂症皮质下异常的概况，这与基于传统荟萃分析方法的结果一致。这项首个谜精神分裂症工作组的研究证实，协作数据分析可以很容易地用于大脑表型和障碍，并鼓励分析和数据共享努力，以加深我们对严重精神疾病的理解。
The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen's d=−0.46), amygdala (d=−0.31), thalamus (d=−0.31), accumbens (d=−0.25) and intracranial volumes (d=−0.12), as well as larger pallidum (d=0.21) and lateral ventricle volumes (d=0.37). Putamen and pallidum volume augmentations were positively associated with duration of illness and hippocampal deficits scaled with the proportion of unmedicated patients. Worldwide cooperative analyses of brain imaging data support a profile of subcortical abnormalities in schizophrenia, which is consistent with that based on traditional meta-analytic approaches. This first ENIGMA Schizophrenia Working Group study validates that collaborative data analyses can readily be used across brain phenotypes and disorders and encourages analysis and data sharing efforts to further our understanding of severe mental illness.