Sulfur Metabolism as a Promising Source of New Antifungal Targets.
Sulfur Metabolism as a Promising Source of New Antifungal Targets.
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DOI：
10.3390/jof8030295
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发表时间：
2022-03-13
期刊：
影响因子：
--
通讯作者：
Amich J
中科院分区：
文献类型：
--
作者：
Amich J
真菌感染对人类健康的威胁越来越大。尽管它们具有临床意义，但临床批准的抗真菌剂的可用性令人惊讶地有限，最近出现的耐药性和快速传播严重加剧了这一点。因此，很明显，迫切需要新的和有效的抗真菌剂。在这种情况下，代谢被认为是新的抗真菌靶点的一个有前途的来源，事实上，正在开发针对代谢途径的新药。真菌硫代谢是特别有趣的，因为它的许多过程是生存力和/或致病性所必需的，并且它与人类代谢有很大的差异。这篇简短的综述将总结我们目前对烟曲霉毒力重要的硫相关基因和途径的了解，从而可以用于药物开发。
Fungal infections are a growing threat to human health. Despite their clinical relevance, there is a surprisingly limited availability of clinically approved antifungal agents, which is seriously aggravated by the recent appearance and fast spread of drug resistance. It is therefore clear that there is an urgent need for novel and efficient antifungals. In this context, metabolism is recognized as a promising source for new antifungal targets and, indeed, there are new drugs in development that target metabolic pathways. Fungal sulfur metabolism is particularly interesting, as many of its processes are essential for viability and/or pathogenicity and it shows substantial differences with human metabolism. This short-review will summarize our current knowledge of sulfur-related genes and routes that are important for Aspergillus fumigatus virulence, which consequently could be pursued for drug development.
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