Effect of chronic exposure to methylmercury on eye movements in Cree subjects
Effect of chronic exposure to methylmercury on eye movements in Cree subjects
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DOI：
10.1007/s00420-003-0480-3
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发表时间：
2004-02-01
影响因子：
3
通讯作者：
Edwards, R
中科院分区：
文献类型：
--
作者：
Beuter, A;Edwards, R
目标。研究慢性甲基汞暴露对魁北克北部克里人眼球运动（追逐、注视和动态扫视）的影响。方法。使用红外眼动记录系统记录慢性甲基汞暴露组Cree受试者（n=36）、帕金森病患者（n=21）和对照组（n=30）的眼动。在水平和垂直坐标轴上记录两眼的追逐、注视、提示和记忆扫视两次。去除眨眼，校正数据。结果。方差分析显示，注视和追求的所有特征以及动态扫视的某些特征都存在显著差异。这些差异有时来自Cree组，有时来自PD组，有时来自两组。结论。结果表明，甲基汞暴露的Cree受试者的眼动与对照组和PD患者的眼动有质的不同。在与对照组年龄匹配的多接触和少接触Cree受试者之间的比较也显示出注视、追求和动态扫视的显著差异。在注视和追求特征，以及提示扫视的准确性和敏速性方面，暴露程度较高组的平均得分与暴露程度较低组和对照组明显不同。这一趋势在其他研究结果中不太明显，因为无法将汞接触的可能影响与可能的文化影响区分开来。进一步的研究应集中在Cree组最具区别性的特征上，例如所有测试的准确性和连贯性以及扫视的清晰度。
Objectives. To examine the effect of chronic exposure to methylmercury on eye movements (pursuit, fixation and dynamic saccades) in Cree subjects from Northern Quebec. Methods. Eye movements were recorded in a group of Cree subjects (n=36) exposed chronically to methylmercury, a group of patients with Parkinson's disease (PD) (n=21), and a group of control subjects (n=30) by use of an infrared eye-movement recording system. Pursuit, fixation, and prompted and remembered saccades were recorded twice for both eyes in the horizontal and vertical axes. Blinks were removed, and data were calibrated. Results. Analyses of variance revealed significant differences for all characteristics examined for fixation and pursuit, and for some characteristics in dynamic saccades. These differences arose sometimes from the Cree group, sometimes from the PD group and sometimes from both groups. Conclusions. The results suggest that eye movements of Cree subjects exposed to methylmercury are qualitatively different from those of both control subjects and patients with PD. Comparisons between more-exposed and less-exposed Cree subjects matched for age with control subjects also showed significant differences for fixation, pursuit and dynamic saccades. The average scores of the more-exposed group were clearly separated from those of the less-exposed and control groups for characteristics of fixation and pursuit, and for accuracy and sharpness of prompted saccades. This trend was less clear in other results where a possible effect of mercury exposure could not be distinguished from a possible cultural effect. Further studies should focus on the most discriminating characteristics for the Cree group, such as measures of accuracy and coherence in all tests and sharpness of saccades.