Acceptor proteins in rat androgenic tissue chromatin.
Acceptor proteins in rat androgenic tissue chromatin.
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大鼠雄激素组织染色质中的受体蛋白。
DOI：
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发表时间：
1976
影响因子：
11.1
通讯作者：
L. Hnilica
中科院分区：
文献类型：
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作者：
L. KLYZSEJKO;J. Chiu;Y. Tsai;L. Hnilica
将染色质分成尿素可溶性染色体非组蛋白（UP）、组蛋白（HP）和DNA相关非组蛋白（NP），结果表明，睾丸和前列腺染色质的NP组分含有5 α-二氢睾酮（17 β-羟基-5 α-雄甾烷-3-酮）及其受体复合物的器官特异性受体。这种雄激素组织染色质的受体能力可以通过DNA相关蛋白的NP部分转移到非靶组织的染色质中。染色质的磷酸化增强了其与受体的结合能力。
Fractionation of chromatin into urea-soluble chromosomal nonhistone proteins (UP), histones (HP), and DNA-associated nonhistone proteins (NP) revealed that the NP fraction from testicular and prostatic chromatin contains organ-specific acceptors for complexes of 5alpha-dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) and its receptor. This acceptor capacity of androgenic tissue chromatin could be transferred to chromatins from non-target tissues with the NP fraction of DNA-associated proteins. Phosphorylation of chromatin enhanced its hormone-receptor binding capacity.