Tumor percent involvement predicts prostate specific antigen recurrence after radical prostatectomy only in men with smaller prostate.
Tumor percent involvement predicts prostate specific antigen recurrence after radical prostatectomy only in men with smaller prostate.
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仅在前列腺较小的男性中，肿瘤受累百分比可预测根治性前列腺切除术后前列腺特异性抗原的复发。
DOI：
10.1016/j.juro.2009.11.046
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Moul,JuddW
中科院分区：
文献类型：
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作者：
Uhlman,MatthewA;Sun,Leon;Stackhouse,DanielleA;Polascik,ThomasJ;Mouraviev,Valdmir;Robertson,CaryN;Albala,DavidM;Moul,JuddW
PurposeWe determined the predictive power of tumor percent involvement on prostate specific antigen recurrence in patients when layered by prostate weight.Materials and MethodsData on 3，057 patients who received radical angiotectomy between 1988 and 2008 was retrieved from our institutional prostate cancer database.有肿瘤累及百分比、前列腺体积和前列腺特异性抗原复发数据的患者纳入分析。根据前列腺体积小于35、35 - 45和大于45 cc将患者分为3组。采用卡方检验和Mann-Whitney检验分析肿瘤累及百分比、手术年龄、种族、前列腺特异性抗原、病理Gleason评分、手术切缘阳性、前列腺外扩展、精囊浸润和手术年份等变量，以确定个体对前列腺特异性抗原复发的影响。肿瘤累及百分比和前列腺特异性抗原作为连续变量进行评价。单变量分析的显着变量包括在多变量考克斯回归分析，比较其对前列腺特异性抗原recurrence.ResultsTumor百分比参与显着预测前列腺特异性抗原复发的男性与一个小的前列腺（p = 0.006），但不是在那些前列腺大于35 cc。黑人是中等前列腺患者前列腺特异性抗原复发的一个轻微显著的预测因子（p = 0.055）。手术年龄是前列腺肥大患者前列腺特异性抗原复发的预测因子（p = 0.003）。前列腺特异性抗原，阳性手术切缘，精囊浸润和病理Gleason评分7或更高的预测前列腺特异性抗原复发的男性与所有prostate sizes.ConclusionsIn男性与前列腺小于35 cc肿瘤百分比参与是一个重要的变量时，评估前列腺特异性抗原复发的风险。在咨询患者和确定根治性前列腺切除术后加强监测的受益者时，应考虑肿瘤累及百分比和前列腺体积。
PurposeWe determined the predictive power of tumor percent involvement on prostate specific antigen recurrence in patients when stratified by prostate weight.Materials and MethodsData on 3,057 patients who underwent radical prostatectomy between 1988 and 2008 was retrieved from our institutional prostate cancer database. Patients with data on tumor percent involvement, prostate volume and prostate specific antigen recurrence were included in analysis. Patients were divided into 3 groups based on prostate volume less than 35, 35 to 45 and greater than 45 cc. The variables tumor percent involvement, age at surgery, race, prostate specific antigen, pathological Gleason score, positive surgical margins, extraprostatic extension, seminal vesicle invasion and surgery year were analyzed using the chi-square and Mann-Whitney tests to determine individual effects on prostate specific antigen recurrence. Tumor percent involvement and prostate specific antigen were evaluated as continuous variables. Significant variables on univariate analysis were included in multivariate Cox regression analysis to compare their effects on prostate specific antigen recurrence.ResultsTumor percent involvement significantly predicted prostate specific antigen recurrence in men with a small prostate (p = 0.006) but not in those with a prostate of greater than 35 cc. Black race was a marginally significant predictor of prostate specific antigen recurrence in men with a medium prostate (p = 0.055). Age at surgery was a predictor of prostate specific antigen recurrence in men with a larger prostate (p = 0.003). Prostate specific antigen, positive surgical margins, seminal vesicle invasion and pathological Gleason score 7 or greater predicted prostate specific antigen recurrence in men with all prostate sizes.ConclusionsIn men with a prostate of less than 35 cc tumor percent involvement is an important variable when assessing the risk of prostate specific antigen recurrence. Tumor percent involvement and prostate volume should be considered when counseling patients and determining who may benefit from heightened surveillance after radical prostatectomy.