Targeted bone remodeling involves BMU steering as well as activation
Targeted bone remodeling involves BMU steering as well as activation
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DOI：
10.1016/j.bone.2007.02.023
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发表时间：
2007-06-01
期刊：
影响因子：
4.1
通讯作者：
Martin, R. B.
中科院分区：
文献类型：
--
作者：
Martin, R. B.
微损伤去除是骨重建的重要功能。实验一再表明，基本多细胞单位(BMus)对皮质骨的重塑是对微损伤的反应，这被称为“靶向重塑”。这篇论文认为，微损伤不仅能够激活新的BMU，而且当它们继续通过骨基质时，还可能吸引或“引导”现有的BMU。初步分析了平均微裂纹长度与BMU吸收空间密度之间的关系，结果表明，BMU的有效面积约为其实际横截面的40倍。将此解释为隧道BMU中的破骨细胞能够感知和引导微损伤的证据，基于Burger等人提出的破骨细胞不仅被引导在主应力方向上的假设，开发了一个用于BMU引导的模型。(Burger，E.H.，Klein-Nulend，J.，Smit，T.H.应变衍生的管状液流动调节重塑骨质中的破骨细胞活动--一项提议。J.Biomech 36(2003)1453-1459)，但也适用于微损害，取决于其邻近程度。(C)2007年，爱思唯尔公司出版。
Microdamage removal is an important function of bone remodeling. Experiments have repeatedly shown that remodeling of cortical bone by Basic Multicellular Units (BMUs) is initiated in response to microdamage, and this has become known as "targeted remodeling". This paper considers the possibility that microdamage is not only able to activate new BMUs, but may also attract or "steer" existing BMUs as they continue to tunnel through the bone matrix. An initial analysis of the relationship of between mean microcrack length and BMU resorption space density in cortical bone indicates that BMUs have an effective area about 40 times greater than their actual cross-section. Interpreting this as evidence that the osteoclasts in a tunneling BMU are able to sense and steer toward microdamage, a model is developed for "BMU steering" based on the hypothesis that osteoclasts are guided not only in the principal stress direction, as proposed by Burger et al. (Burger, E.H., Klein-Nulend, J., Smit, T.H. Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon-a proposal. J. Biomech 36 (2003) 1453-1459), but also toward microdamage,.depending on its proximity. (c) 2007 Published by Elsevier Inc.