Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense
Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense
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DOI：
10.1007/s13659-011-0030-8
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发表时间：
2012-02-22
影响因子：
4.7
通讯作者：
Hao XJ
中科院分区：
文献类型：
--
作者：
Liu WX;Tang GH;He HP;Zhang Y;Li SL;Hao XJ
从海南五味子的枝叶中分离得到4个新的柠檬苦素类化合物--Ddysohainaninins A-D(1-4)和2个新的三萜类化合物--Dysohainaninins E和F(5和6)以及7个已知化合物。用多种光谱方法确定了新化合物的结构。已知化合物ent-19-nor-4，16，18-trihydroxy-8(14)-pomaren-15-one(13)对HL-60、A-549、MCF7和SW480细胞具有体外杀伤活性，其IC50值分别为24.3、28.1、30.7和22.5µM。化合物2和3用卤水对虾进行了杀虫活性测试，结果表明它们都是无效的。本文的补充材料可通过10.1007/s13659-0110030-8获得，授权用户可访问。
Four new limonoids, dysohainanins A–D (1–4), and two new triterpenoids, dysohainanins E and F (5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The structures of the new compounds were determined by a variety of spectroscopic methods. The cytotoxic activities of these compounds were evaluated, and the known compound ent-19-nor-4,16,18-trihydroxy-8(14)-pomaren-15-one (13) showed in vitro cytotoxicity against HL-60, A-549, MCF-7, and SW480 cells, with IC50 values of 24.3, 28.1, 30.7, and 22.5 µM, respectively. Compounds 2 and 3 were tested their insecticidal activities using brine shrimp and both of them were inactive. Supplementary material is available for this article at 10.1007/s13659-011-0030-8 and is accessible for authorized users.