Specialization of the Human Hippocampal Long Axis Revisited.
Specialization of the Human Hippocampal Long Axis Revisited.
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重新审视人类海马长轴的专业化。
DOI：
10.1101/2023.12.19.572264
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Buckner,RandyL
中科院分区：
文献类型：
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作者：
Angeli,PeterA;DiNicola,LaurenM;Saadon-Grosman,Noam;Eldaief,MarkC;Buckner,RandyL
海马体沿其长轴具有解剖学差异。在这里，我们使用两个独立数据集（N = 11 和 N = 9）中的网络锚定精密功能 MRI 并结合行为分析（N = 266 和 N = 238）探索人类海马长轴的功能专业化。功能连接分析表明，前海马体优先与与记忆相关的大脑网络相关，而后海马体选择性地包含与与行为显着性相关的独特网络相关的区域。放置在海马体内的种子区域再现了不同的大脑网络。使用任务数据对前海马区和后海马区进行功能表征，识别并复制功能性双解离。海马前区对记忆和想象未来很敏感，特别是跟踪场景构建的过程，而海马后区则对奇怪的检测任务中的目标以及任务块之间的转换表现出短暂的反应。这些发现表明，沿着人类海马体长轴的意外专业化具有反映伙伴大脑网络功能特性的差异反应。
The hippocampus possesses anatomical differences along its long axis. Here, we explored the functional specialization of the human hippocampal long axis using network-anchored precision functional MRI in two independent datasets (N = 11 and N = 9) paired with behavioral analysis (N = 266 and N = 238). Functional connectivity analyses demonstrated that the anterior hippocampus was preferentially correlated with a cerebral network associated with remembering, while the posterior hippocampus selectively contained a region correlated with a distinct network associated with behavioral salience. Seed regions placed within the hippocampus recapitulated the distinct cerebral networks. Functional characterization of the anterior and posterior hippocampal regions using task data identified and replicated a functional double dissociation. The anterior hippocampal region was sensitive to remembering and imagining the future, specifically tracking the process of scene construction, while the posterior hippocampal region displayed transient responses to targets in an oddball detection task and to transitions between task blocks. These findings suggest an unexpected specialization along the long axis of the human hippocampus with differential responses reflecting the functional properties of the partner cerebral networks.