HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.
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AID is critical for immunoglobulin class switch DNA recombination (CSR) and somatic hypermutation (SHM). Here we showed that AID expression was induced by the HoxC4 homeodomain transcription factor, which bound to a highly conserved HoxC4-Oct site in the Aicda promoter. This site functioned in synergy with a conserved Sp-NF-κB-binding site. HoxC4 was preferentially expressed in germinal center B cells and was upregulated by CD154:CD40 engagement, lipopolysaccharide and interleukin-4. HoxC4 deficiency resulted in impaired CSR and SHM, due to decreased AID expression and not other putative HoxC4-dependent activity. Enforced expression of AID in Hoxc4−/− B cells fully restored CSR. Thus, HoxC4 directly activates the Aicda promoter, thereby inducing AID expression, CSR and SHM.
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影响因子：
4.4
作者：
Dedeoglu, F;Horwitz, B;Geha, RS
通讯作者：
Geha, RS
影响因子：
32.4
作者：
Kwon, Kyongrim;Hutter, Caroline;Busslinger, Meinrad
通讯作者：
Busslinger, Meinrad
影响因子：
20.3
作者：
MEAZZA, R;FAIELLA, A;CORTE, G
通讯作者：
CORTE, G
影响因子：
20.3
作者：
Pasqualucci, L;Guglielmino, R;Polakiewicz, R
通讯作者：
Polakiewicz, R
在免疫反应中的辅助表达调节。
DOI：
10.1084/jem.20061952
发表时间：
2007-05-14
期刊：
The Journal of experimental medicine
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作者：
通讯作者：
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