Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages.
Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages.
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靶向葡萄糖颗粒封装的胆汁纳米颗粒抑制了人类巨噬细胞中的HIV生长。
DOI：
10.1155/2016/8520629
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发表时间：
2016
影响因子：
--
通讯作者：
Ostroff GR
中科院分区：
文献类型：
--
作者：
Soto ER;O'Connell O;Dikengil F;Peters PJ;Clapham PR;Ostroff GR
葡聚糖颗粒（GP）是来源于面包酵母（酿酒酵母）细胞壁的中空多孔3-5 μm微球。1，3-β-葡聚糖外壳通过表达β-葡聚糖受体的吞噬细胞提供受体介导的摄取。GP已用于包封在中空GP内或结合到化学衍生的GP表面的广泛的有效载荷（DNA、siRNA、蛋白质、小分子和纳米颗粒）的巨噬细胞靶向递送。镓纳米颗粒已被提议作为针对HIV感染的抑制剂。在此，与游离镓纳米颗粒相比，使用GP靶向镓的巨噬细胞提供了更有效的镓递送和巨噬细胞中HIV感染的抑制。
Glucan particles (GPs) are hollow, porous 3–5 μm microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-β-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing β-glucan receptors. GPs have been used for macrophage-targeted delivery of a wide range of payloads (DNA, siRNA, protein, small molecules, and nanoparticles) encapsulated inside the hollow GPs or bound to the surface of chemically derivatized GPs. Gallium nanoparticles have been proposed as an inhibitory agent against HIV infection. Here, macrophage targeting of gallium using GPs provides for more efficient delivery of gallium and inhibition of HIV infection in macrophages compared to free gallium nanoparticles.