Role of germinal centers for the induction of broadly-reactive memory B cells.
Role of germinal centers for the induction of broadly-reactive memory B cells.
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DOI：
10.1016/j.coi.2017.03.002
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发表时间：
2017-04
影响因子：
7
通讯作者：
Kelsoe G
中科院分区：
文献类型：
--
作者：
Takahashi Y;Kelsoe G
病毒特异性记忆 B 细胞 (Bmem) 在防御变异病毒方面发挥着至关重要的作用。识别这些变异病毒的能力（定义为抗体广度）是在 Bmem 群体中通过两种截然不同的途径实现的，即种系编码的交叉反应性和亲和力驱动的生发中心 (GC) 中保守病毒表位的体细胞进化。后一类具有广泛反应性的 Bmem 细胞本身不具有交叉反应性，但会结合对病毒适应性至关重要的表位。尽管这些保守表位通常具有弱免疫原性，但 GC 反应令人惊讶地允许 B 细胞持续存活/增殖，这些 B 细胞以低亲和力结合或与隐性表位发生反应，从而增加了它们招募记忆的机会。在这篇综述中，我们讨论了 B 细胞记忆对病毒抗原变异的适应性策略。
Virus-specific memory B cells (Bmem) play a crucial role in protecting against variant viruses. The ability to recognize these variant viruses, defined as antibody breadth, is achieved in Bmem populations by two very different pathways, germline-encoded cross-reactivity and affinity-driven, somatic evolution in germinal centers (GCs) for conserved viral epitopes. The latter class of broadly-reactive Bmem cells are not cross-reactive per se, but bind epitopes crucial for viral fitness. Although these conserved epitopes are often weakly immunogenic, the GC reaction is surprisingly permissive for the continued survival/proliferation of B cells that bind with low affinity or react to cryptic epitopes, increasing their chance of memory recruitment. In this review, we discuss the adaptive strategies of B-cell memory to viral antigenic variations.