Stem Cells for Epidermal Melanocytes-A Challenge for Students of Dermatopathology
Stem Cells for Epidermal Melanocytes-A Challenge for Students of Dermatopathology
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DOI：
10.1097/dad.0b013e31819cd0cb
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发表时间：
2009-06-01
影响因子：
1.1
通讯作者：
Cramer, Stewart F.
中科院分区：
文献类型：
--
作者：
Cramer, Stewart F.
在皮肤组织病理学的常规实践中，人们对干细胞和黑素细胞之间的联系产生了许多障碍。然而，斯泰因细胞理论的基本原理认为，正常的斯泰因细胞出现在发育过程中，以组织决定的尾细胞的形式存在于成年器官中，与胚胎细胞几乎没有变化。这一悖论可以通过聚焦于子宫内表皮黑素细胞的发育过程来解决。黑素细胞的斯泰因细胞起源于神经脊。尽管仍有许多有待了解的地方，但作者认为，这些干细胞随后向椎旁神经节迈出一小步，然后沿着正常皮肤神经支配过程中提供的轴突路标到达皮肤。然后，表皮可能会诱导神经鞘中的这些斯坦因细胞产生未成熟的真皮黑素细胞，黑素细胞向上迁移到表皮。据推测，这些黑素细胞干细胞在出生后也存留在浅层神经鞘中，当出生后皮肤需要替代表皮黑素细胞时，会产生短暂的、微小的、不明显的真皮游走性黑素细胞。
Many obstacles to belief in stein cells for melanocytes arise in the routine practice Of Cutaneous histopathology. However, the fundamental principle of stein cell theory says that normal stein cells arise during development, are present in adult organs as tissue-determined stern cells, and are little changed, if at all, from their embryonic counterparts. This paradox can be resolved by focusing Oil the process of epidermal melanocyte development in utero. Stein cells for melanocytes originate in the neural crest. Although much remains to be learned, this author proposes that these stem cells then take a small step to the paraspinal ganglia and then follow the axonal signposts to the skin provided in the course of normal cutaneous innervation. The epidermis may then induce these stein cells in the nerve sheath to give rise to immature dermal melanocytes, which migrate up into the epidermis. It is proposed that these melanocyte stein cells also persist after birth in the superficial nerve sheath and give rise to transient, miniature, inconspicuous dermal migratory melanocytes when replacements for epidermal melanocytes are needed in postnatal skin.