Elevated emotional contagion in a mouse model of Alzheimer's disease is associated with increased synchronization in the insula and amygdala.
Elevated emotional contagion in a mouse model of Alzheimer's disease is associated with increased synchronization in the insula and amygdala.
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DOI：
10.1038/srep46262
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发表时间：
2017-04-07
影响因子：
4.6
通讯作者：
Jeong Y
中科院分区：
文献类型：
--
作者：
Choi J;Jeong Y
情感传染是同理心的一种原始形式，在阿尔茨海默病(AD)患者中会增加；然而，这一特性背后的机制尚未完全阐明。在这项研究中，观察到的恐惧条件作用被用来测量阿尔茨海默病小鼠模型的情绪传染水平。同时记录双侧前岛、杏仁基底外侧核、扣带回前皮质和脾后皮质的局部场电位，以研究相关的脑网络变化。与AD患者的结果一致，11个月大的AD模型小鼠在观察到的恐惧条件反射中表现出显著更高的冰冻水平，表明与年龄匹配的野生型小鼠相比，情感传染增加。此外，11个月大的AD模型小鼠的左侧前脑岛和右侧基底外侧杏仁核在观察到同种疾病的痛苦时显示出持续的同步增加。这些变化在其他年龄组或野生型对照中没有出现。此外，在观察到的恐惧条件反射中，前脑岛内的淀粉样斑块负荷与冰冻程度显著相关。综上所述，这项研究揭示了前脑岛和基底外侧杏仁核之间增加和持续的网络同步性，这构成了人类的突出网络，这是AD小鼠模型中情绪感染升高的潜在机制。
Emotional contagion, a primitive form of empathy, is heightened in patients with Alzheimer’s disease (AD); however, the mechanism underlying this attribute has not been thoroughly elucidated. In this study, observational fear conditioning was performed to measure emotional contagion levels in a mouse model of AD. Simultaneous recording of local field potentials in the bilateral anterior insula, basolateral amygdala, anterior cingulate cortex, and retrosplenial cortex was also conducted to investigate related brain network changes. Consistent with the results obtained with AD patients, 11-month-old AD model mice exhibited significantly higher freezing levels in observational fear conditioning, indicating elevated emotional contagion compared to age-matched wild-type mice. Furthermore, the left anterior insula and right basolateral amygdala of 11-months-old AD model mice indicated sustained increases in synchronization when they observed the suffering of conspecifics. These changes did not appear in other age groups or wild-type controls. Additionally, the amyloid plaque burden within the anterior insula was significantly correlated with the freezing levels in observational fear conditioning. Taken together, this study reveals increased and sustained network synchrony between the anterior insula and basolateral amygdala, which comprise a salience network in humans, as a potential mechanism for elevated emotional contagion in a mouse model of AD.