Differential expression of Fos protein after transection of the rat infraorbital nerve in the trigeminal nucleus caudalis
Differential expression of Fos protein after transection of the rat infraorbital nerve in the trigeminal nucleus caudalis
复制标题
大鼠眶下神经横断后三叉神经尾核Fos蛋白的差异表达
DOI：
10.1016/s0006-8993(97)00633-1
复制
发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
T. Nishimori
中科院分区：
文献类型：
--
作者：
R. Terayama;N. Nagamatsu;T. Ikeda;Tadashi Nakamura;Omar Ibna Faizur Rahman;S. Sakoda;R. Shiba;T. Nishimori
为了确定神经损伤对Fos表达的影响，在成年大鼠组织损伤后，观察了三叉神经尾侧核Fos阳性神经元的时空分布，以眶下神经为对照，切断该神经以及福尔马林注射的有害化学刺激。Fos免疫反应显着升高，在板层I和II的唯一同侧核尾侧2小时后，这些手术和有害的化学刺激。与眶下神经切断相比，福尔马林注射和组织损伤后Fos阳性神经元的分布受到限制。一天后，组织损伤和神经横断，然而，Fos阳性神经元分布在两侧的第三层和第四层延伸喙尾和内外侧在这个核，这持续了2周的研究期间。神经切断侧Fos阳性神经元数目明显少于对侧，而组织损伤组Fos阳性神经元沿头尾轴沿着对称分布。神经切断组和组织损伤组对侧的神经功能无明显差异。显示Fos表达减少的吻尾侧水平大致对应于该核中受损神经的中枢终止部位，这表明在同侧尾侧核的第III层和第IV层神经元中Fos表达减少的初级传入神经的作用。
To determine the effects of nerve injury on Fos expression, temporal and spatial distributions of Fos-positive neurons in the trigeminal nucleus caudalis were examined after tissue injury for isolation of the infraorbital nerve as controls and transection of this nerve as well as noxious chemical stimulation by formalin injection in adult rats. Fos immunoreactivity was markedly elevated in laminae I and II of the only ipsilateral nucleus caudalis 2 h after these surgical procedures and noxious chemical stimulation. The distributions of Fos-positive neurons were restricted rostro-caudally following formalin injection and tissue injury compared to transection of the infraorbital nerve. One day after tissue injury and nerve transection, however, Fos-positive neurons were distributed bilaterally in laminae III and IV extending rostro-caudally and medio-laterally in this nucleus, and this persisted over the 2-week study period. The number of Fos-positive neurons in the side ipsilateral to nerve transection was markedly less than that in the contralateral side whereas positive neurons in the tissue injured rats were distributed symmetrically along the rostro-caudal axis. There was no difference in the contralateral sides between nerve transection and tissue injury groups. The rostro-caudal level showing reduction in Fos expression corresponded roughly to the sites of central termination of the injured nerve in this nucleus, suggesting a role for the primary afferents in the reduction of Fos expression in laminae III and IV neurons of the ipsilateral nucleus caudalis.
三叉神经部分在脑干中诱导 Fos 样免疫反应性 (FLI)，并降低感觉皮层中的 FLI。
DOI：
10.1016/0169-328x(89)90057-0
发表时间：
1989
期刊：
Brain research. Molecular brain research
影响因子：
--
作者：
Sharp,FR;Griffith,J;Gonzalez,MF;Sagar,SM
通讯作者：
Sagar,SM