Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development
Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development
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保幼激素合成和信号干扰引发枝角动物（水蚤）雄性后代诱导和种群下降：回顾和不良结果途径开发
DOI：
10.1016/j.aquatox.2021.106058
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发表时间：
2022
影响因子：
4.5
通讯作者：
Iguchi Taisen
中科院分区：
文献类型：
--
作者：
Toyota Kenji;Watanabe Haruna;Hirano Masashi;Abe Ryoko;Miyakawa Hitoshi;Song You;Sato Tomomi;Miyagawa Shinichi;Tollefsen Knut Erik;Yamamoto Hiroshi;Tatarazako Norihisa;Iguchi Taisen
幼体激素（JH）是一类调节节肢动物幼虫发育、蜕皮、变态、繁殖和表型可塑性的多功能激素。基于JH在节肢动物生活史中的重要性，人们设计了许多类似JH的昆虫生长调节剂（IGRs）来控制农业和水产养殖中的有害昆虫。这些JH类似物（JHAs）也可能对非目标物种造成危害，引起意想不到的内分泌干扰（ED）效应，如蜕皮和变态缺陷、幼虫致死和性别身份的破坏。本文综述了jh在淡水枝海甲壳类动物（如水蚤）中对JHA触发的内分泌干扰输出的介导作用的现有知识，以建立对JHA影响的系统理解。基于目前的知识，研究人员开发了解决jha介导的枝海洋ED效应的不良结局途径（AOPs），该途径导致雄性后代的产生和随后的种群减少。根据既定指南评估AOPs的证据权重（WoE）。综述和AOP的发展旨在介绍目前对JH通路的科学认识，并为未来生态毒理学研究和监管过程中jha的分层测试策略和新的风险评估方法的发展提供有力的参考。
Juvenile hormone (JH) are a family of multifunctional hormones regulating larval development, molting, metamorphosis, reproduction, and phenotypic plasticity in arthropods. Based on its importance in arthropod life histories, many insect growth regulators (IGRs) mimicking JH have been designed to control harmful insects in agriculture and aquaculture. These JH analogs (JHAs) may also pose hazards to nontarget species by causing unexpected endocrine-disrupting (ED) effects such as molting and metamorphosis defects, larval lethality, and disruption of the sexual identity. This critical review summarizes the current knowledge of the JH-mediated effects in the freshwater cladoceran crustaceans such asDaphniaspecies on JHA-triggered endocrine disruptive outputs to establish a systematic understanding of JHA effects. Based on the current knowledge, adverse outcome pathways (AOPs) addressing the JHA-mediated ED effects in cladoceran leading to male offspring production and subsequent population decline were developed. The weight of evidence (WoE) of AOPs was assessed according to established guidelines. The review and AOP development aim to present the current scientific understanding of the JH pathway and provide a robust reference for the development of tiered testing strategies and new risk assessment approaches for JHAs in future ecotoxicological research and regulatory processes.