Myocyte Enhancer Factor-2 (MEF2) in Diseases of Central Nervous System: A Mini Review
Myocyte Enhancer Factor-2 (MEF2) in Diseases of Central Nervous System: A Mini Review
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DOI：
10.14218/erhm.2015.00001
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Jing Wang
中科院分区：
文献类型：
--
作者：
Jing Wang
肌细胞增强因子 2 (MEF2) 是最初在肌肉细胞中发现的转录因子家族，最近发现在中枢神经系统中表达。它参与突触消除的调节，这是决定神经元命运和功能的重要过程。最近的研究表明，MEF2 转录因子参与突触可塑性、学习和记忆的分子机制以及涉及痴呆和神经退行性疾病的其他过程。这篇综述总结了理解 MEF2 在神经退行性疾病（如阿尔茨海默病、帕金森病和脆性 X 综合征）中的作用的最新进展。
Myocyte enhancer factor-2 (MEF2), a family of transcription factors originally identified in muscles cells, was recently found to be expressed in the central nervous system. It is involved in the modulation of synapse elimination, a vital process that determines the fate and function of neurons. Recent studies suggested that MEF2 transcription factors are involved in synaptic plasticity, the molecular mechanism underlying learning and memory and other processes involved in dementia and neurodegenerative disease. This review summarizes recent advancements in understanding the role of MEF2 in neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, and Fragile X syndrome.