A randomized clinical trial of an individualized home-based exercise programme for women with fibromyalgia
A randomized clinical trial of an individualized home-based exercise programme for women with fibromyalgia
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DOI：
10.1093/rheumatology/kei032
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发表时间：
2005-11-01
期刊：
影响因子：
5.5
通讯作者：
Dobkin, PL
中科院分区：
文献类型：
--
作者：
Da Costa, D;Abrahamowicz, M;Dobkin, PL
Objective.确定为期12周的个体化家庭锻炼计划对纤维肌痛（FM）妇女的身体功能、疼痛严重程度和心理困扰的疗效。79名初步诊断为FM的妇女被随机分配到12周的个性化家庭中等强度运动计划或常规护理对照组。结果是功能能力（纤维肌痛影响问卷），疼痛严重程度和心理困扰。在研究开始时、12周干预结束时、干预完成后3个月和9个月测量结果。在意向治疗分析的基础上，观察到运动组参与者在治疗后3个月和9个月的功能能力显著改善，这些参与者在进入研究时功能障碍更严重。在治疗后3个月和9个月，干预的平均估计获益超过10分[-12.3（95% CI，-21.9至-2.8）; -10.8（95% CI，-21.5至-0.2）]。与对照组相比，运动组在治疗后的上身疼痛有统计学显著改善。这些上身疼痛的组间差异在治疗后3个月和9个月保持不变。在下体疼痛和心理困扰方面没有发现统计学显著的组间差异。以家庭为基础的运动，一个相对低成本的治疗方式，有可能改善FM的重要健康结果。
Objective. To determine the efficacy of a 12-week individualized home-based exercise programme on physical functioning, pain severity and psychological distress for women with fibromyalgia (FM).Methods. Seventy-nine women with a primary diagnosis of FM were randomized to a 12-week individualized home-based moderate-intensity exercise programme or to a usual care control group. Outcomes were functional capacity (Fibromyalgia Impact Questionnaire), pain severity and psychological distress. Outcomes were measured at study entry, at the end of the 12-week intervention, and at 3 and 9 months following completion of the intervention.Results. On the basis of intention-to-treat analyses, a significant improvement in functional capacity at 3 and 9 months following treatment for participants in the exercise group who were more functionally disabled at study entry was observed. At both 3 and 9 months post-treatment, the mean estimated benefit of the intervention was more than 10 points [-12.3 (95% CI, -21.9 to -2.8); -10.8 (95% CI, -21.5 to -0.2)]. Compared with the control group, statistically significant improvements in upper body pain were evident in the exercise group at post-treatment. These between-group differences in upper body pain were maintained at 3 and 9 months post-treatment. No statistically significant group differences on lower body pain and psychological distress were found.Conclusions. Home-based exercise, a relatively low-cost treatment modality, has the potential to improve important health outcomes in FM.