Characterization of an idiotype-binding helper cell required for the formation of timothy grass pollen antigen-B-specific IgE.
Characterization of an idiotype-binding helper cell required for the formation of timothy grass pollen antigen-B-specific IgE.
复制标题
梯牧草花粉抗原 B 特异性 IgE 形成所需的独特型结合辅助细胞的表征。
DOI：
10.1159/000234087
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Malley,A
中科院分区：
文献类型：
--
作者：
Malley,A
Experiments were conducted using an excess of biosynthetically labeled timothy grass pollen antigen-B-specific (AgB-specific) T helper factor (THF) with enriched T cells, enriched B cells, or normal spleen cells to determine the site of the THFaction. These studies indicated that the labeled THFbound preferentially to T cells, and analysis of the cell surface characteristics suggested that these T cells were Lyt 123+cells. A panning technique using partially purified AgB-specific THF-coated Petri dishes depleted a population of idiotype-binding T cells that appears to be required for the formation of AgB-specific IgE antibody.
