The effect of fecapentaenes on nuclear aberrations in murine colonic epithelial cells.
The effect of fecapentaenes on nuclear aberrations in murine colonic epithelial cells.
复制标题
非卡戊烯对小鼠结肠上皮细胞核畸变的影响。
DOI：
10.1016/0304-3835(87)90163-7
复制
发表时间：
1987
期刊：
影响因子：
9.7
通讯作者：
J. Krepinsky
中科院分区：
文献类型：
--
作者：
D. Vaughan;R. Furrer;J. Baptista;J. Krepinsky
Fecapentaenes, human fecal mutagens of bacterial origin, were intrarectally administered to mice in suppository form. Despite the strong, positive mutagenic response of fecanpentaenes using Ames tester strains TA 98 and TA 100, no increase in nuclear aberrations, taken as a measure of genotoxicity in colonic epithelial cells, was observed over control levels. In fecapentaene treated animals, however, the incidence of mitotic figures was increased above control levels to values comparable to those observed in mice treated with the known colon carcinogen,N-ethyl-N-nitrosourea. Thus, it would appear that fecapentaenes are not cytotoxic to murine colonic epithelia as judged by the nuclear aberration assay.
影响因子：
5.1
作者：
HIRAI, N;KINGSTON, DGI;WILKINS, TD
通讯作者：
WILKINS, TD