Cellular and immunologic mechanisms in atopic dermatitis
Cellular and immunologic mechanisms in atopic dermatitis
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DOI：
10.1067/mjd.2001.109815
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发表时间：
2001-01-01
影响因子：
13.8
通讯作者：
Soter, NA
中科院分区：
文献类型：
--
作者：
Leung, DYM;Soter, NA
特应性皮炎是一种慢性炎症性皮肤病，通常与呼吸道过敏有关。特应性皮炎的发展是环境、免疫、遗传和药理学因素复杂相互关系的结果。努力了解这些因素的相对贡献导致研究寻求识别相关的效应细胞和介质参与特应性皮炎的发病机制。这些因素包括局部细胞因子释放的模式、辅助性T细胞的分化、IgE的多种作用、皮肤定向细胞反应、感染因子和超级抗原。本文回顾了特应性皮炎的细胞和免疫机制，并讨论了如何理解它们在炎症过程中的作用，从而改善特应性皮炎的治疗。
Atopic dermatitis is a chronic inflammatory skin disease that is frequently associated with respiratory allergies. Atopic dermatitis develops as a result of a complex interrelationship of environmental, immunologic, genetic, and pharmacologic factors. Efforts to understand the relative contributions of these factors have led to research seeking to identify the relevant effector cells and mediators involved in the pathogenesis of atopic dermatitis. These factors include the pattern of local cytokine release, the differentiation of helper T cells, multiple roles of IgE, skin-directed cell responses, infectious agents, and superantigens. This article reviews these cellular and immunologic mechanisms underlying atopic dermatitis and discusses how an understanding of their role in the inflammatory process may lead to improved treatments for atopic dermatitis.