Selective breeding to develop lines of baboons with high and low blood pressure.
Selective breeding to develop lines of baboons with high and low blood pressure.
复制标题
选择性育种，培育高血压和低血压狒狒品系。
DOI：
10.1161/01.hyp.21.6.1076
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
McGillJr,HC
中科院分区：
文献类型：
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作者：
Carey,D;Kammerer,CM;Shade,RE;Rice,KS;McGillJr,HC
高血压和低血压狒狒品系是通过选择性育种培育出来的。通过直接动脉插管在氯胺酮固定下测量 456 只成年野生狒狒的血压。选择血压高出累积平均值两个标准差的男性和血压高出和低于累积平均值一个标准差的女性作为祖细胞。高位雄性与高位雌性交配，低位雄性与低位雌性交配。我们使用简化的系绳协议和数据收集软件程序测量了 100 名后代（54 名男性和 46 名女性，年龄超过 44 个月）的血压和血浆肾素活性。高线的平均夜间收缩压和舒张压为 126/72，低线的平均夜间收缩压和舒张压为 114/65 mm Hg。收缩压 (12 mm Hg) 和舒张压 (7 mm Hg) 的线差异显着 (p < 0.001)。血浆肾素活性（1.1 [ng/mL]/hr）的线差异不显着。子代压力范围为 84/49 至 191/126 毫米汞柱。血压或血浆肾素活性线差异不存在性别影响。收缩压的遗传力为0.46+/-0.19，舒张压的遗传力为0.32+/-0.19。这些结果表明，通过选择性选育和严格的血压测量，可以培育出血压差异显着的狒狒品系。
Lines of baboons with high and low blood pressure were developed by selective breeding. Blood pressure was measured in 456 adult feral baboons under ketamine immobilization by direct arterial cannulation. Males with blood pressures two standard deviations and females with blood pressures one standard deviation above and below the cumulative mean were selected as progenitors. High males were mated with high females and low males were mated with low females. We measured blood pressure and plasma renin activity on 100 progeny, 54 males and 46 females, greater than 44 months of age with an abbreviated tether protocol and software program for data collection. Mean systolic and diastolic nighttime pressures for the high line were 126/72 and for the low line were 114/65 mm Hg. Line differences for systolic (12 mm Hg) and for diastolic (7 mm Hg) pressures were significant (p < 0.001). The line difference for plasma renin activity (1.1 [ng/mL]/hr) was not significant. Progeny pressures ranged from 84/49 to 191/126 mm Hg. There was no sex effect on blood pressure or plasma renin activity line differences. Heritability of systolic pressure was 0.46 +/- 0.19 and of diastolic pressure was 0.32 +/- 0.19. These results indicate that, by selective breeding and rigorous measurement of blood pressure, lines of baboons with significant difference in blood pressure can be developed.