EFFECT OF DIET ON THERMOGENESIS IN ACQUIRED LIPODYSTROPHY
EFFECT OF DIET ON THERMOGENESIS IN ACQUIRED LIPODYSTROPHY
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DOI：
10.1016/0026-0495(79)90090-8
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发表时间：
1979-01-01
影响因子：
9.8
通讯作者：
SIMS, EAH
中科院分区：
文献类型：
--
作者：
ROBBINS, DC;DANFORTH, E;SIMS, EAH
本文报告了一名18岁获得性脂肪代谢障碍女性和一名23岁正常女性的碳水化合物、脂肪、蛋白质和总热量摄入的变化对代谢率和甲状腺激素的影响。脂肪营养不良受试者的静息代谢率升高，并直接随热量摄入而变化。代谢率在补充蛋白质饮食3天后最高，在禁食3天后最低。血清三碘甲状腺原氨酸（T3）浓度的脂肪营养不良的主题是在正常范围内，但直接与饮食的热量含量的变化。T3在蛋白质补充期间最高，禁食3天后最低。对照组受试者的静息代谢率仅在补充蛋白质饮食3天后才超过正常范围，并在禁食3天后降至正常低值。与脂肪营养不良受试者中的发现相反，T3浓度在每次3-6天饮食改变后稳定。在脂肪营养不良的受试者中存在相对的代谢不稳定性，这可能与将能量储存为脂肪的能力降低有关。脂肪营养不良受试者的代谢率正常，进食量减少（1800卡/天）。T3在调节这些过程中的作用（如果有的话）尚不清楚。患有脂肪营养不良的受试者可以表现出一种形式的饮食诱导的产热。
The effect of variation of intake of carbohydrate, fat, protein and total calories on the metabolic rate and thyroid hormones in an 18 yr old female with total acquired lipodystrophy and a 23 yr old normal female control subject. The lipodystrophic subject''s resting metabolic rates, were elevated and varied directly with the caloric intake. The metabolic rates were highest after 3 days of the protein-supplemented diet and lowest after a 3 day fast. Serum triiodothyronine (T3) concentrations of the lipodystrophic subject were within the normal range but varied directly with the caloric content of the diet. T3 was highest during the period of protein supplementation and lowest after the 3 day fast. The resting metabolic rate rose beyond the normal range in the control subject only after 3 days of the protein-supplemented diet and fell to low normal values after the 3 day fast. In contrast to the finding in the lipodystrophic subject, T3 concentrations were stable after each 3-6 day dietary alteration. There is relative metabolic lability in the lipodystrophic subject and this may be related to the diminished capacity to store energy as fat. Metabolic rates, were normal in the lipodystrophic subject, consuming reduced amounts of food (1800 cal/day). The role, if any, of T3 in modulating these processes is unclear. The subject with lipodystrophy may demonstrate a form of dietary-induced thermogenesis.