Secondary stone formation 8 weeks after percutaneous nephrolithotomy treatment: A case report.
Secondary stone formation 8 weeks after percutaneous nephrolithotomy treatment: A case report.
复制标题
经皮肾镜取石术后8周继发结石1例报告
DOI：
10.1097/md.0000000000026091
复制
发表时间：
2021-05-28
期刊：
影响因子：
1.6
通讯作者：
Liang H
中科院分区：
文献类型：
--
作者：
Deng Q;Wang H;Lai Y;Liang H
本文报道了一例复发性肾结石患者在半年内接受了三次手术，位于同一位置，高通量测序数据显示肾脓液和尿液样本中存在不同的物种，这表明可以通过尿液中的细菌来判断部分肾感染或结石形成。女患者，43岁，于2020年4月13日因左腰痛、发热3天转诊至作者科室。肾结石和肾积水通过泌尿系统计算机断层扫描来确定。2020年4月20日和2020年6月15日，患者在全麻下两次成功行经皮肾镜取石术。在最后一次入院时完成对患者6个月内的健康和饮食习惯的调查。用红外光谱仪对第二例肾结石标本进行成分分析。对第三例肾结石(肾脓液，三联体)进行微生物基因组测序，并对手术前后的尿样进行16S核糖核酸测序。经皮肾镜取石后，左肾结石基本清除，结石分析显示主要成分为一水草酸钙、二氧化硅和少量脱水草酸钙。尽管尿液样本显示出差异，但肾脓液和尿液样本具有相同的物种。目前尚不清楚是否可以通过尿液中的细菌来判断部分肾脏感染或结石形成的前景。
This work reports a patient with recurrent renal calculi subjected to three surgeries in half a year to be in the same position, and the high-throughput sequencing data showed different species in the renal pus and urine samples, which suggested that partial renal infection or stone formation can be judged by the bacteria in urine. The female patient aged 43 years was referred to the authors’ department on April 13, 2020, due to left waist pain and fever for 3 days. Kidney stones and hydronephrosis were determined by a urinary system computed tomography scan. On April 20, 2020 and June 15, 2020, the patient was successfully treated with left percutaneous nephrolithotomy twice under general anesthesia. An investigation on the health and eating habits of the patient within 6 months was completed at the last admission. The components of the second renal calculus sample were analyzed with an infrared spectrum analyzer. The third renal stone (renal pus, triplicates) was subjected to microbial metagenome sequencing, and urine samples before and after surgery were subjected to 16S RNA sequencing by SEQHEALTH (Wuhan, China). After percutaneous nephrolithotomy, the left kidney stones were basically cleared, stone analysis revealed that the main components were calcium oxalate monohydrate, silica, and a small amount of calcium oxalate dehydrate. Although the urine samples exhibited differences, the renal pus and urine sample shared a single species. It is not clear that the prospects of partial renal infection or stone formation can be judged by the bacteria in urine.