Inhibition of ATPases activity in channel catfish brain by kepone and its reduction product
Inhibition of ATPases activity in channel catfish brain by kepone and its reduction product
复制标题
酮及其还原产物对斑点叉尾鮰脑内ATP酶活性的抑制作用
DOI：
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发表时间：
1975
影响因子：
2.7
通讯作者：
R. Koch
中科院分区：
文献类型：
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作者：
D. Desaiah;R. Koch
现代化学害虫防治方法造成世界水道污染，从而危及包括鱼类在内的水生动物的生命。尽管关于所谓的硬农药的残留毒性和其他环境因素有大量信息，但关于这些有机氯农药的毒性作用机制的信息很少。近年来，我们（KOCH 1969b、KOCH 1969/70、CUTKOMP 等人 1971a）和其他人（MATSUMURA 等人 1969、AKERA 等人 1971、DAVIS 等人 1972）提出 ATPase 酶系统作为这些有机氯化合物的可能靶位点。 Kepone R 是一种有机氯杀虫剂，已广泛用于控制食叶昆虫。然而，与其他氯化烃一样，该化合物的作用方式迄今为止尚不清楚。
Modern pest control methods by chemicals cause contamination of world waterways and thus endanger the life of aquatic fauna, including fish. Although voluminous information is available on the residual toxicity and other environmental factors of the socalled hard pesticides, there is little information available on the mechanism of toxic action of these organochlorine pesticides. In recent years, the ATPase enzyme system(s) has been proposed by us (KOCH 1969b, KOCH 1969/70, CUTKOMP et al. 1971a) and others (MATSUMURA et al. 1969, AKERA et al. 1971, DAVIS et al. 1972) as a possible target site for these organochlorine compounds. Kepone R, an organochlorine insecticide has been widely used for controlling leaf-eating insects. However, the mode of action of this compound, like other chlorinated hydrocarbons, is not clearly understood to date.