The effects of atypical antipsychotic medications on psychosocial outcomes
The effects of atypical antipsychotic medications on psychosocial outcomes
复制标题
DOI：
10.1016/s0920-9964(02)00379-1
复制
发表时间：
2003-09-01
影响因子：
4.5
通讯作者：
Toombs, GA
中科院分区：
文献类型：
--
作者：
Corrigan, PW;Reinke, RR;Toombs, GA
这篇综述探讨了这样一个问题：非典型抗精神病药物是否能改善心理社会结局？通过检查比较精神药物与传统抗精神病药物或其他非典型药物的效果的研究。作者回顾了非典型抗精神病药物的随机临床试验，包括心理社会变量作为结局。31项已发表的研究对12，000多人进行了研究，结果表明，与传统抗精神病药物相比，非典型药物导致阴性症状显着改善。对心理社会功能和生活质量的总体评估的影响好坏参半，只有大约一半的研究报告有显著改善。奥氮平在心理社会功能方面取得了最好的结果;发现Remoxipride在这些变量上几乎没有显著变化。这篇综述提供了一些非典型抗精神病药物可能对某些社会心理有直接影响的证据。严重精神疾病导致的残疾。(C)2002 Elsevier Science B. V.保留所有权利。
This review examines the question-Do atypical antipsychotic medications improve psychosocial outcomes?-by examining studies that compared the effects of atypicals to conventional antipsychotics or to other atypical medications. The authors reviewed randomized clinical trials of atypical antipsychotic medication that included psychosocial variables as outcomes. Findings from 31 published studies on more than 12,000 individuals generally showed that atypical medications led to significant improvements in negative symptoms compared to conventional antipsychotics. Effects on global assessment of psychosocial functioning and on the quality of life were mixed with only about half the studies reporting significant improvements. Olanzapine yielded the best results on psychosocial functioning; remoxipride was found to yield few significant changes on these variables. This review provides evidence that some atypical antipsychotics may have direct effects on some of the psychosocial. disabilities that result from serious mental illness. (C) 2002 Elsevier Science B.V. All rights reserved.