UMBILICAL AMINO-ACID-CONCENTRATIONS IN NORMAL AND GROWTH-RETARDED FETUSES SAMPLED INUTERO BY CORDOCENTESIS
UMBILICAL AMINO-ACID-CONCENTRATIONS IN NORMAL AND GROWTH-RETARDED FETUSES SAMPLED INUTERO BY CORDOCENTESIS
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DOI：
10.1016/0002-9378(90)90860-a
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发表时间：
1990-01-01
影响因子：
9.8
通讯作者：
BATTAGLIA, FC
中科院分区：
文献类型：
--
作者：
CETIN, I;CORBETTA, C;BATTAGLIA, FC
胎儿血浆氨基酸浓度获得脐带穿刺在妊娠中期在11个正常（适合胎龄）胎儿和妊娠晚期在12个小的妊娠-AE胎儿，并在剖宫产在14个正常足月婴儿。在正常胎儿中，总摩尔氨基酸浓度和胎儿/母体总摩尔浓度比在第二和第三孕期之间没有显着变化。胎儿和母亲的大多数氨基酸浓度显着相关，在妊娠中期和妊娠晚期。小于胎龄的胎儿具有显著较低的总α-葡萄糖浓度。这主要是因为支链氨基酸缬氨酸、亮氨酸和异亮氨酸以及赖氨酸和丝氨酸的减少。小于胎龄儿孕妇的母体动脉血苯丙氨酸、精氨酸、组氨酸和丙氨酸浓度升高。因此，在胎儿/母体比例恒定的正常胎儿中，妊娠中期和妊娠晚期之间的氨基酸浓度仅有微小变化。在小于胎龄婴儿中，α-氨基氮和大多数必需氨基酸在分娩前的子宫内数周内是可证明的。
Fetal plasma amino acid concentrations were obtained by cordocentesis at midgestation in 11 normal (appropriate for gestational age) fetuses and at late gestation in 12 small-for-gestational-ae fetuses, and at cesarean section in 14 normal term infants. In normal fetuses total molar amino acid concentrations and fetal/maternal total molar concentration ratios did not change significantly between the second and third trimesters. Fetal and maternal concentrations of most amino acids were significantly correlated at both midgestation and late gestation. Small-for-gestational-age fetuses had significantly lower concentrations of total .alpha.-aminonitrogen; this was mainly because of a reduction of the branched chain amino acids valine, leucine, and isoleucine, and of lysine and serine. Maternal arterial concentrations of phenylalanine, arginine, histidine, and alanine were elevated in small-for-gestational-age pregnancies. Thus there are only minor changes in amino acid concentrations between midgestation and late gestation in normal fetuses with a constant fetal/maternal ratio. In small-for-gestational-age infants a significant reduction in .alpha.-aminonitrogen and in most essential amino acids was demonstrable in utero weeks before delivery.