ALTERED ARTERIAL ION-TRANSPORT AND ITS REVERSAL IN ALDOSTERONE HYPERTENSIVE RAT
ALTERED ARTERIAL ION-TRANSPORT AND ITS REVERSAL IN ALDOSTERONE HYPERTENSIVE RAT
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DOI：
10.1152/ajpheart.1982.243.6.h927
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
JONES, AW
中科院分区：
文献类型：
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作者：
GARWITZ, ET;JONES, AW
在醛固酮治疗的大鼠中，血管离子代谢的改变先于血压升高。早在开始输注醛固酮后 1 周就检测到主动脉和股动脉中 42K+ 和 36Cl- 周转率的增加。经过三周的恢复期后，这些血管变化完全逆转。在收缩压显着升高之前，还观察到去甲肾上腺素 (NE) 对主动脉 42K+ 转换的影响的敏感性增加。在注射醛固酮 4 周的高血压大鼠的血管中也发现钠转运增强。高血压血管中 24Na+ 流出的 K 敏感成分显着升高。 Na泵活性的增加似乎补偿了被动膜对Na的渗透性的增加，因为醛固酮处理并未改变细胞Na水平。当细胞外 Ca 被去除时，醛固酮治疗大鼠的主动脉中 42K+ 周转发生更快的增加。钙依赖性过程充分稳定血管平滑肌膜的能力受损可能会导致血管离子转运的改变。明显改变的血管电解质代谢是大鼠醛固酮诱导的高血压发展的重要致病机制。
Alterations in vascular ionic metabolism preceded the onset of elevated blood pressure in the aldosterone-treated rat. Increases in 42K+ and 36Cl- turnover in the aorta and femoral artery were detected as early as 1 wk after the start of aldosterone infusion. These vascular changes were completely reversed after a 3-wk recovery period. An increased sensitivity to the effect of norepinephrine (NE) on aortic 42K+ turnover was also observed prior to a significant rise in systolic blood pressure. Enhanced Na transport was also found in vessels from hypertensive rats infused with aldosterone for 4 wk. The K-sensitive component of the 24Na+ efflux was significantly elevated in vessels from hypertensives. This increase in Na pump activity appeared to compensate for an increase in passive membrane permeability to Na in that cell Na levels were not altered by aldosterone treatment. A more rapid increase in 42K+ turnover occurred in aorta from aldosterone-treated rats when extracellular Ca was removed. An impaired ability of Ca-dependent processes to adequately stabilize the vascular smooth muscle membrane may contribute to altered vascular ion transport. Evidently altered vascular electrolyte metabolism is an important pathogenic mechanism in the development of aldosterone-induced hypertension in the rat.