Linkage between susceptibility of Phlebotomus papatasi to Leishmania major and hunger tolerance.
Linkage between susceptibility of Phlebotomus papatasi to Leishmania major and hunger tolerance.
复制标题
白蛉对大型利什曼原虫的易感性与饥饿耐受性之间的联系。
DOI：
10.1017/s0031182002002147
复制
发表时间：
2002
期刊：
影响因子：
2.4
通讯作者：
Jacobson,RL
中科院分区：
文献类型：
--
作者：
Schlein,Y;Jacobson,RL
主要利什曼原虫的媒介帕帕塔白蛉对病原体的易感性存在遗传差异。感染的代价似乎是如此之大，选择对利什曼原虫易感苍蝇可能会发生，除非敏感性是补偿的一些优势。番木瓜疫霉传播疫源地主要是在干旱的栖息地，季节性的脱水和热的压力减少了植物叶片中的糖的数量。白蛉以这些树叶为食，由于缺乏必需的糖，只有少数白蛉能存活足够长的时间，以存款产卵并传播利什曼原虫。这种关联表明对L.严重感染可能与对糖剥夺的有利耐受性有关。在这里，我们表明，沙漠沙蝇，提供了过量的糖，成为逐步抵抗感染。选择生存条件下的糖增加了父母和第一代后代的易感性超过2倍。植物的叶子，苍蝇自然饲料，含有更多的糖在灌溉比干旱的栖息地。大约85%的第一代苍蝇殖民从沙漠栖息地保留实验利什曼原虫感染相比，25%的后代苍蝇从灌溉网站。
Phlebotomus papatasi sand flies, the vectors of Leishmania major, differ genetically in their susceptibility to the pathogens. The costs of infection appear to be so great that selection against Leishmania-susceptible flies could presumably occur, unless susceptibility is compensated for by some advantage. Foci of P. papatasi-transmitted L. major are mainly found in arid habitats where seasonal stress of dehydration and heat reduces the quantity of sugar in plant leaves. The sand flies feed on these leaves and with the lack of essential sugar only a few survive long enough to deposit eggs and transmit Leishmania. This association suggested that susceptibility to L. major infection may be linked with advantageous tolerance of sugar deprivation. Here we show that desert sand flies, provided with excess sugar, became progressively resistant to infection. Selection for survival under sugar-poor conditions increased the susceptibility of parent and first-generation offspring by more than 2-fold. The leaves of plants, on which flies naturally feed, contain more sugar in irrigated than in arid habitats. About 85% of first-generation flies colonized from a desert habitat retain experimental Leishmania infection compared to 25% of offspring of flies from irrigated sites.